Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Osteoporosis associated with long-term glucocorticoid therapy remains a common and
serious bone disease. Additionally, in recent years it has become clear that more subtle …

Glucocorticoids are steroid hormones that once bound to their receptor interact with the DNA
binding domain. Almost 1000–2000 genes are sensitive to their effects, including …

Abstract 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) interconverts the inactive
glucocorticoid cortisone and its active form cortisol. It is widely expressed and, although …

Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …

Since the discovery of cortisone in the 1940s and its early success in treatment of
rheumatoid arthritis, glucocorticoids have remained the mainstay of anti-inflammatory …

There is evidence that plasma cortisol concentration can be either increased or decreased
in patients with depression and related anxiety and stress-related disorders; the exact …

Apoptosis might be involved in the reduction of the thyroid cell population in
physiopathological situations such as goitre involution and autoimmune deleterious …

Background Despite their efficacy in the treatment of chronic inflammation, the prolonged
application of therapeutic glucocorticoids (GCs) is limited by significant systemic side effects …