Since the publication of the 2nd edition of White and Panjabi׳ s textbook, Clinical
Biomechanics of the Spine in 1990, there has been considerable research on the …

Few human tissues have functions as closely linked to the composition of their extracellular
matrices as the intervertebral disc. In fact, the hallmark of intervertebral disc degeneration …

Homocysteine (Hcy) is an amino acid involved in gene methylation. Plasma concentration of
Hcy is elevated in the pathological condition hyperhomocysteinemia (HHcy), which …

Discectomy procedures alleviate disability caused by intervertebral disc (IVD) herniation, but
do not repair herniation-induced annulus fibrosus (AF) defects. Cell therapy shows promise …

Intervertebral disc degeneration and associated low back and neck pain is a ubiquitous
health condition that affects millions of people world-wide, and causes high incidence of …

Despite considerable efforts to develop cellular, molecular, and structural repair strategies
and restore intervertebral disk function after injury, the basic biology underlying …

Biomechanical testing methodologies for the spine have developed over the past 50 years.
During that time, there have been several paradigm shifts with respect to techniques. These …

Animal models have been invaluable in the identification of molecular events occurring in
and contributing to intervertebral disc (IVD) degeneration and important therapeutic targets …

Conventional microdiscectomy treatment for intervertebral disc herniation alleviates pain but
does not repair the annulus fibrosus, resulting in a high incidence of recurrent herniation …

One of the causes of intervertebral disc degeneration (IVDD) is nucleus pulposus cell (NPC)
death, possibly apoptosis. In this study, we explored the role of the Nrf2/Sirt3 pathway and …