Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

SE Arnold, Z Arvanitakis… - Nature Reviews …, 2018 - nature.com
Considerable overlap has been identified in the risk factors, comorbidities and putative
pathophysiological mechanisms of Alzheimer disease and related dementias (ADRDs) and …

The epidemiology of Parkinson's disease: risk factors and prevention

A Ascherio, MA Schwarzschild - The Lancet Neurology, 2016 - thelancet.com
Since 2006, several longitudinal studies have assessed environmental or behavioural
factors that seem to modify the risk of develo** Parkinson's disease. Increased risk of …

Incidence of Parkinson disease in North America

AW Willis, E Roberts, JC Beck, B Fiske, W Ross… - npj Parkinson's …, 2022 - nature.com
Parkinson disease (PD) is the second most common age-related neurodegenerative
condition diagnosed in North America. We recently demonstrated, using multiple …

Type 2 diabetes as a determinant of Parkinson's disease risk and progression

H Chohan, K Senkevich, RK Patel… - Movement …, 2021 - Wiley Online Library
Abstract Background Type 2 diabetes (T2DM) and Parkinson's disease (PD) are prevalent
diseases that affect an aging population. Previous systematic reviews and meta‐analyses …

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative …

S Ghaisas, J Maher, A Kanthasamy - Pharmacology & therapeutics, 2016 - Elsevier
The gut microbiome comprises the collective genome of the trillions of microorganisms
residing in our gastrointestinal ecosystem. The interaction between the host and its gut …

Insulin resistance and Parkinson's disease: a new target for disease modification?

D Athauda, T Foltynie - Progress in neurobiology, 2016 - Elsevier
There is growing evidence that patients with Type 2 diabetes have an increased risk of
develo** Parkinson's disease and share similar dysregulated pathways suggesting …

Efficacy of repetitive transcranial magnetic stimulation in Parkinson's disease: a systematic review and meta-analysis of randomised controlled trials

W Zhang, B Deng, F **e, H Zhou, JF Guo, H Jiang… - …, 2022 - thelancet.com
Background Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive form of
brain stimulation that positively regulates the motor and non-motor symptoms of Parkinson's …

Brain insulin resistance: role in neurodegenerative disease and potential for targeting

C Hölscher - Expert opinion on investigational drugs, 2020 - Taylor & Francis
Introduction: This review evaluates the novel strategy of treating Alzheimer's and Parkinson's
disease (AD and PD) withdrugs that initially have been developed to treat type 2 diabetes …

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

H Vicente Miranda, ÉM Szegő, LMA Oliveira, C Breda… - Brain, 2017 - academic.oup.com
α-Synuclein misfolding and aggregation is a hallmark in Parkinson's disease and in several
other neurodegenerative diseases known as synucleinopathies. The toxic properties of α …

[HTML][HTML] Reducing neuroinflammation via therapeutic compounds and lifestyle to prevent or delay progression of Parkinson's disease

E Kip, LC Parr-Brownlie - Ageing Research Reviews, 2022 - Elsevier
Parkinson's disease (PD) is the second most common age-associated neurodegenerative
disorder and is characterised by progressive loss of dopamine neurons in the substantia …