Ethnopharmacological relevance Network pharmacology is a new discipline based on
systems biology theory, biological system network analysis, and multi-target drug molecule …

Traditional Chinese medicine (TCM) is a precious treasure of the Chinese nation and has
unique advantages in the prevention and treatment of diseases. The holistic view of TCM …

Intestinal-type gastric cancer is preceded by premalignant lesions, including chronic
atrophic gastritis and intestinal metaplasia. In this study, we constructed a single-cell atlas …

Traditional Chinese medicine (TCM) has a long history of viewing an individual or patient as
a system with different statuses, and has accumulated numerous herbal formulae. The …

In the post-genomic era, the elucidation of the relationship between the molecular origins of
diseases and their resulting phenotypes is a crucial task for medical research. Here, we use …

Given the functional interdependencies between the molecular components in a human cell,
a disease is rarely a consequence of an abnormality in a single gene, but reflects the …

Drug-like compounds are most of the time denied approval and use owing to the
unexpected clinical side effects and cross-reactivity observed during clinical trials. These …

Background Many existing bioinformatics predictors are based on machine learning
technology. When applying these predictors in practical studies, their predictive …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …