Intermittent hypoxemia and OSA: implications for comorbidities

NA Dewan, FJ Nieto, VK Somers - Chest, 2015 - Elsevier
OSA is a common chronic disorder that is associated with significant morbidity and mortality
including cardiovascular, metabolic, and neurocognitive disease and increased cancer …

Obstructive sleep apnea and comorbidities: a dangerous liaison

MR Bonsignore, P Baiamonte, E Mazzuca… - Multidisciplinary …, 2019 - Springer
Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated
with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged …

International consensus statement on obstructive sleep apnea

JL Chang, AN Goldberg, JA Alt… - International forum of …, 2023 - Wiley Online Library
Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

Clinical consequences and economic costs of untreated obstructive sleep apnea syndrome

M Knauert, S Naik, MB Gillespie… - World Journal of …, 2015 - mednexus.org
Objective: To provide an overview of the healthcare and societal consequences and costs of
untreated obstructive sleep apnea syndrome. Data sources: PubMed database for English …

Hypoxia-inducible factors and cancer

JC Jun, A Rathore, H Younas, D Gilkes… - Current sleep medicine …, 2017 - Springer
Abstract Purpose of Review Hypoxia-inducible factors (HIFs) mediate the transcription of
hundreds of genes that allow cells to adapt to hypoxic environments. In this review, we …

ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia

Y Chao, J Shang, W Ji - Biochemical and biophysical research …, 2020 - Elsevier
Obstructive sleep apnea (OSA) is closely associated with cancer progression and cancer-
related mortality. N6-methyladenosine (m 6 A) is involved in the process of intermittent …

Sleep apnea and cancer: analysis of a nationwide population sample

D Gozal, SA Ham, B Mokhlesi - sleep, 2016 - academic.oup.com
Abstract Study Objectives: Epidemiological evidence from relatively small cohorts suggests
that obstructive sleep apnea (OSA) is associated with higher cancer incidence and mortality …

Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer

I Hunyor, KM Cook - American Journal of Physiology …, 2018 - journals.physiology.org
Obstructive sleep apnea (OSA) is common and linked to a variety of poor health outcomes. A
key modulator of this disease is nocturnal intermittent hypoxia. There is striking …

Obstructive sleep apnea and incident cancer: a large retrospective multicenter clinical cohort study

T Kendzerska, M Povitz, RS Leung, MI Boulos… - … Biomarkers & Prevention, 2021 - AACR
Background: To examine the association between the severity of obstructive sleep apnea
(OSA) and nocturnal hypoxemia with incident cancer. Methods: This was a multicenter …

Obesity, sleep apnea, and cancer

I Almendros, MA Martinez-Garcia, R Farré… - International Journal of …, 2020 - nature.com
The interest on a potential association between cancer and sleep-disordered breathing
(SDB) has clearly gained substantial traction over the last several years. This novel …