Optical microscopy has for centuries been a key tool to study living cells with minimum
invasiveness. The advent of single molecule techniques over the past two decades has …

Individual proteins and protein complexes undergo various motion types, including free
diffusion, confinement, subdiffusion and directed motion. Different motion behaviours reflect …

Deviations from Brownian motion leading to anomalous diffusion are found in transport
dynamics from quantum physics to life sciences. The characterization of anomalous diffusion …

Diffusion plays a crucial role in many biological processes including signaling, cellular
organization, transport mechanisms, and more. Direct observation of molecular movement …

The regulation of transcription requires the coordination of numerous activities on DNA, yet
how transcription factors mediate these activities remains poorly understood. Here, we use …

It is well established that a wide variety of phenomena in cellular and molecular biology
involve anomalous transport eg the statistics for the motility of cells and molecules are …

The dynamics of constituents and the surface response of cellular membranes—also in
connection to the binding of various particles and macromolecules to the membrane—are …

Summary β-arrestin plays a key role in G protein-coupled receptor (GPCR) signaling and
desensitization. Despite recent structural advances, the mechanisms that govern receptor-β …

Genome dynamics are intimately linked to the regulation of gene expression, the most
fundamental mechanism in biology, yet we still do not know whether the very process of …

Single-particle tracking techniques enable investigation of the complex functions and
interactions of individual particles in biological environments. Many such techniques exist …