Previous attempts to identify a unified theory of brain serotonin function have largely failed to
achieve consensus. In this present synthesis, we integrate previous perspectives with new …

To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …

Remote memories depend on coordinated activity in the hippocampus and frontal cortices,
but the timeline of these interactions is debated. Astrocytes sense and modify neuronal …

The serotonin system modulates a wide variety of emotional behaviors and states, including
reward processing, anxiety, and social interaction. To reveal the underlying patterns of …

The dorsal raphe (DR) constitutes a major serotonergic input to the forebrain and modulates
diverse functions and brain states, including mood, anxiety, and sensory and motor …

Neurons in the mammalian brain are not limited to releasing a single neurotransmitter but
often release multiple neurotransmitters onto postsynaptic cells. Here, we review recent …

Neurons that synthesize and release 5-hydroxytryptamine (5-HT; serotonin) express a core
set of genes that establish and maintain this neurotransmitter phenotype and distinguish …

Reversible silencing of neuronal activity is a powerful approach for isolating the roles of
specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal …

Signals from the central circadian pacemaker, the suprachiasmatic nucleus (SCN), must be
decoded to generate daily rhythms in hormone release. Here, we hypothesized that the SCN …

The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been
implicated in a wide variety of behavioral and neurological disorders. The DRN is …