Stroke is a major cause of mortality and disability globally, with ischemic stroke (IS)
accounting for over 80% of all stroke cases. The pathological process of IS involves …

Non-alcoholic fatty liver disease (NAFLD) has become the most epidemic liver disease
worldwide owing to rapid changes in lifestyle over the past few decades. This chronic …

Macroautophagy/autophagy, an evolutionarily conserved process, plays an important role in
the regulation of immune inflammation and nervous system homeostasis. However, the …

Background Our previous studies have shown that berberine can improve the nerve function
deficits in ischemic stroke by inhibiting inflammation. The cellular communication between …

As an important post-translational modification, lysine ubiquitination participates in
numerous biological processes and is involved in human diseases, whereas the site …

Tumor necrosis factor α (TNF-α) is a pro-inflammatory cytokine capable of inducing extrinsic
apoptosis and necroptosis. Tumor necrosis factor receptor-associated factor 6 (TRAF6), an …

Background and Purpose—Ischemic stroke is one of the leading causes of morbidity and
mortality worldwide and a major cause of long-term disability. Recently, long noncoding …

Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are
correlated with aggressive growth and other malignant characteristics in a wide variety of …

Individuals who suffer from post-CA (cardiac arrest) brain injury experience higher mortality
and more severe functional disability. Neuroinflammation has been identified as a vital factor …

Cerebrovascular diseases (CVDs) are a major threat to global health. Elucidation of the
molecular mechanisms underlying the pathology of CVDs is critical for the development of …