Cellular senescence is a stress response that accompanies stable exit from the cell cycle.
Classically, senescence, particularly in human cells, involves the p53 and p16/Rb pathways …

Lipids are essential components of a cell providing energy substrates for cellular processes,
signaling intermediates, and building blocks for biological membranes. Lipids are constantly …

A major challenge of the post-genomics era is to define the connectivity of protein
phosphorylation networks. Here, we quantitatively delineate the insulin signaling network in …

Nutrient sensing by mechanistic target of rapamycin complex 1 (mTORC1) on lysosomes
and late endosomes (LyLEs) regulates cell growth. Many factors stimulate mTORC1 activity …

Autophagy is a catabolic pathway that has a fundamental role in the adaptation to fasting
and primarily relies on the activity of the endolysosomal system, to which the …

The eukaryotic V-type adenosine triphosphatase (V-ATPase) is a multi-subunit membrane
protein complex that is evolutionarily related to F-type adenosine triphosphate (ATP) …

Cell growth is a highly regulated, plastic process. Its control involves balancing positive
regulation of anabolic processes with negative regulation of catabolic processes. Although …

Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of
late endosomes and lysosomes (LELs), and ORP1L specifically localizes to LELs. Here, we …

Recent evidence indicates that the importance of the lysosome in cell metabolism and
organism physiology goes far beyond the simple disposal of cellular garbage. This dynamic …

Background The muscle protein anabolic response to contraction and feeding may be
blunted in older adults. Acute bouts of exercise can improve the ability of amino acids to …