Aβ-oligomers: A potential therapeutic target for Alzheimer's disease
The cascade of amyloid formation relates to multiple complex events at the molecular level.
Previous research has established amyloid plaque deposition as the leading cause of …
Previous research has established amyloid plaque deposition as the leading cause of …
Rationally designed peptides and peptidomimetics as inhibitors of amyloid-β (Aβ) aggregation: Potential therapeutics of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no clinically
accepted treatment to cure or halt its progression. The worldwide effort to develop peptide …
accepted treatment to cure or halt its progression. The worldwide effort to develop peptide …
Peptides for therapy and diagnosis of Alzheimer's disease
S Aileen Funke, D Willbold - Current pharmaceutical design, 2012 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with devastating
effects. The greatest risk factor to develop AD is age. Today, only symptomatic therapies are …
effects. The greatest risk factor to develop AD is age. Today, only symptomatic therapies are …
Sequence and structure-based peptides as potent amyloid inhibitors: A review
Misfolded and natively disordered globular proteins tend to aggregate together in an
interwoven fashion to form fibrous, proteinaceous deposits referred to as amyloid fibrils …
interwoven fashion to form fibrous, proteinaceous deposits referred to as amyloid fibrils …
Molecules that target beta‐amyloid
The devastating effects of Alzheimer's and related amyloidogenic diseases have inspired
the synthesis and evaluation of numerous ligands to understand the molecular mechanism …
the synthesis and evaluation of numerous ligands to understand the molecular mechanism …
Inhibition of insulin fibrillogenesis with targeted peptides
TJ Gibson, RM Murphy - Protein Science, 2006 - Wiley Online Library
Under conditions of acidic pH and elevated temperature, insulin partially unfolds and
aggregates into highly structured amyloid fibrils. Aggregation of insulin leads to loss of …
aggregates into highly structured amyloid fibrils. Aggregation of insulin leads to loss of …
Oligomeric forms of insulin amyloid aggregation disrupt outgrowth and complexity of neuron-like PC12 cells
Formation of protein amyloid fibrils consists of a series of intermediates including oligomeric
aggregates, proto-fibrillar structures, and finally mature fibrils. Recent studies show higher …
aggregates, proto-fibrillar structures, and finally mature fibrils. Recent studies show higher …
Breaker peptides against amyloid-β aggregation: a potential therapeutic strategy for Alzheimer's disease
N Ghosh, LM Kundu - Future Medicinal Chemistry, 2021 - Taylor & Francis
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, for which blocking
the early steps of extracellular misfolded amyloid-β (Aβ) aggregation is a promising …
the early steps of extracellular misfolded amyloid-β (Aβ) aggregation is a promising …
Transthyretin as both a sensor and a scavenger of β-amyloid oligomers
Transthyretin (TTR) is a homotetrameric transport protein, assembled from monomers that
each contain two four-stranded β-sheets and a short α-helix and loop. In the tetramer, the …
each contain two four-stranded β-sheets and a short α-helix and loop. In the tetramer, the …
Design of peptidyl compounds that affect β-amyloid aggregation: importance of surface tension and context
TJ Gibson, RM Murphy - Biochemistry, 2005 - ACS Publications
Self-association of β-amyloid (Aβ) peptide into cross-β-sheet fibrils induces cellular toxicity
in vitro and is linked with progression of Alzheimer's disease. Previously, we demonstrated …
in vitro and is linked with progression of Alzheimer's disease. Previously, we demonstrated …