Diabetic retinal disease (DRD), the most common complication of diabetes and a leading
cause of blindness in working age individuals, is now understood to be a form of sensory …

Although diabetic retinopathy (DR) is clinically diagnosed as a vascular disease, many
studies find retinal neuronal and visual dysfunction before the onset of vascular DR. This …

Diabetic retinopathy is now well understood as a neurovascular disease. Significant deficits
early in diabetes are found in the inner retina that consists of bipolar cells that receive inputs …

Given the ever-increasing prevalence of type 2 diabetes and obesity, the pressure on global
healthcare is expected to be colossal, especially in terms of blindness. Electroretinogram …

Purpose: Proliferative diabetic retinopathy (PDR) is characterized by retinal new vessel
formation, pointing to the importance of the antiangiogenic treatment in PDR. Hepatocyte …

The pig has been used as a large animal model in biomedical research for many years and
its use continues to increase because induced mutations phenocopy several inherited …

Retinal signaling under dark-adapted conditions is perturbed during early diabetes.
Additionally, dopamine, the main neuromodulator of retinal light adaptation, is diminished in …

Recent evidence suggests that melanopsin-expressing intrinsically photosensitive retinal
ganglion cells (ipRGCs), a neuronal class regulating non-image forming (NIF) vision and …

Previous study has identified SLC7A14 as a new causative gene of retinitis pigmentosa
(RP). However, the role of SLC7A14 has not been fully characterized. The goal of this study …

The intricate functionality of the vertebrate retina relies on the interplay between
neurotransmitter activity and calcium (Ca2+) dynamics, offering important insights into …