Recent applications of 1, 3-thiazole core structure in the identification of new lead compounds and drug discovery

A Ayati, S Emami, A Asadipour, A Shafiee… - European Journal of …, 2015 - Elsevier
Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in …

Recent developments in azole compounds as antibacterial and antifungal agents

XM Peng, GX Cai, CH Zhou - Current topics in medicinal …, 2013 - ingentaconnect.com
Azole compounds are an important class of nitrogen heterocycles with electron-rich
property. This special structure endows azole-based derivatives easily bind with the …

Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives

CI Lino, IG de Souza, BM Borelli, TTS Matos… - European Journal of …, 2018 - Elsevier
In the search for new antifungal agents, a novel series of fifteen hydrazine-thiazole
derivatives was synthesized and assayed in vitro against six clinically important Candida …

[HTML][HTML] Green synthesis and molecular docking study of some new thiazoles using terephthalohydrazide chitosan hydrogel as ecofriendly biopolymeric catalyst

JY Al-Humaidi, SM Gomha, NAA El-Ghany, B Farag… - Catalysts, 2023 - mdpi.com
Terephthalohydrazide chitosan hydrogel (TCs) was prepared and investigated as an
ecofriendly biopolymeric catalyst for synthesis of some novel thiazole and thiadiazole …

[HTML][HTML] New platinum (II) and palladium (II) complexes of coumarin-thiazole Schiff base with a fluorescent chemosensor properties: Synthesis, spectroscopic …

Ö Şahin, ÜÖ Özdemir, N Seferoğlu, ZK Genc… - … of Photochemistry and …, 2018 - Elsevier
A new coumarin-thiazole based Schiff base (Ligand, L) and its Pd (II), Pt (II) complexes;([Pd
(L) 2] and [Pt (L) 2]), were synthesized and characterized using spectrophotometric …

Synthesis, antitumor activity and mechanism of action of novel 1, 3-thiazole derivatives containing hydrazide–hydrazone and carboxamide moiety

H He, X Wang, L Shi, W Yin, Z Yang, H He… - Bioorganic & medicinal …, 2016 - Elsevier
Abstract A series of novel 2, 4, 5-trisubstituted 1, 3-thiazole derivatives containing hydrazide–
hydrazine, and carboxamide moiety including 46 compounds T were synthesized, and …

Antimicrobial activity, synergism and inhibition of germ tube formation by Crocus sativus-derived compounds against Candida spp.

S Carradori, P Chimenti, M Fazzari… - Journal of enzyme …, 2016 - Taylor & Francis
The limited arsenal of synthetic antifungal agents and the emergence of resistant Candida
strains have prompted the researchers towards the investigation of naturally occurring …

The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase

AM Omar, S Ihmaid, ESE Habib, SS Althagfan… - Bioorganic …, 2020 - Elsevier
A series of novel 2-Amino-4-Methylthiazole analogs were developed via three-step reaction
encompassing hydrazine-1-carboximidamide motif to combat Gram-positive and Gram …

Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1, 3-thiazolidin-4-one derivatives

C De Monte, S Carradori, B Bizzarri, A Bolasco… - European journal of …, 2016 - Elsevier
On the basis of the recent findings about the biological properties of thiazolidinones and
taking into account the encouraging results about the antifungal activity of some (thiazol-2 …

Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents

S Carradori, F Ortuso, A Petzer, D Bagetta… - European Journal of …, 2018 - Elsevier
Abstract New 4-(3-nitrophenyl) thiazol-2-ylhydrazone derivatives are proposed as dual-
target-directed monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE) inhibitors …