G protein-coupled receptors (GPCRs) constitute a superfamily of cell-surface receptors
which share a common topology of seven transmembrane domains and modulate a variety …

Olfactory receptors (ORs) and down-stream functional signaling molecules adenylyl cyclase
3 (AC3), olfactory G protein α subunit (Gαolf), OR transporters receptor transporter proteins 1 …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

GPR56 is an adhesion G protein-coupled receptor that plays a key role in cortical
development. Mutations to GPR56 in humans cause malformations of the cerebral cortex …

α1‐Adrenoceptors are seven transmembrane domain GPCRs involved in numerous
physiological functions controlled by the endogenous catecholamines, noradrenaline and …

Linked Article This article is commented on by Michel, MC, pp. 429‐430 of this issue. To
view this commentary visit http://dx. doi. org/10.1111/bph. 13379. Background and Purpose …

Abstract α1‐adrenoceptor antagonists are widely used for hypertension (eg, doxazosin) and
benign prostatic hypertrophy (BPH, eg, tamsulosin). Some antidepressants and …

The nomenclature of the Adrenoceptors has been agreed by the NC-IUPHAR Subcommittee
on Adrenoceptors [58], see also [180]. Adrenoceptors, α1α1-Adrenoceptors are activated by …

Olfactory receptors (ORs) comprise more than half of the large class IG protein-coupled
receptor (GPCR) superfamily. Although cloned over a decade ago, little is known about their …

Regulators of G-protein signaling (RGS) proteins act directly on Gα subunits to increase the
rate of GTP hydrolysis and to terminate signaling. However, the mechanisms involved in …