Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

Y Jiang, AA Trotsyuk, S Niu, D Henn, K Chen… - Nature …, 2023 - nature.com
Abstract 'Smart'bandages based on multimodal wearable devices could enable real-time
physiological monitoring and active intervention to promote healing of chronic wounds …

[HTML][HTML] Navigating the collagen jungle: the biomedical potential of fiber organization in cancer

JN Ouellette, CR Drifka, KB Pointer, Y Liu… - Bioengineering, 2021 - mdpi.com
Recent research has highlighted the importance of key tumor microenvironment features,
notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and …

[HTML][HTML] Recent advancements in optical harmonic generation microscopy: Applications and perspectives

S JamesDarian, J CampagnolaPaul - BME frontiers, 2021 - spj.science.org
Second harmonic generation (SHG) and third harmonic generation (THG) microscopies
have emerged as powerful imaging modalities to examine structural properties of a wide …

Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis

AL Wishart, SJ Conner, JR Guarin, JP Fatherree… - Science …, 2020 - science.org
The extracellular matrix (ECM), a major component of the tumor microenvironment,
promotes local invasion to drive metastasis. Here, we describe a method to study whole …

Disrupting mechanotransduction decreases fibrosis and contracture in split-thickness skin grafting

K Chen, D Henn, M Januszyk, JA Barrera… - Science Translational …, 2022 - science.org
Burns and other traumatic injuries represent a substantial biomedical burden. The current
standard of care for deep injuries is autologous split-thickness skin grafting (STSG), which …

microRNA-33 deficiency in macrophages enhances autophagy, improves mitochondrial homeostasis, and protects against lung fibrosis

F Ahangari, NL Price, S Malik, M Chioccioli… - JCI …, 2023 - pmc.ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease. Recent
findings have shown a marked metabolic reprogramming associated with changes in …

Disrupting biological sensors of force promotes tissue regeneration in large organisms

K Chen, SH Kwon, D Henn, BA Kuehlmann… - Nature …, 2021 - nature.com
Tissue repair and healing remain among the most complicated processes that occur during
postnatal life. Humans and other large organisms heal by forming fibrotic scar tissue with …

Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings

K Chen, D Sivaraj, MF Davitt… - Wound Repair and …, 2022 - Wiley Online Library
Biological scaffolds such as hydrogels provide an ideal, physio‐mimetic of native
extracellular matrix (ECM) that can improve wound healing outcomes after cutaneous injury …

The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation

V Vorstandlechner, M Laggner, D Copic, K Klas… - Nature …, 2021 - nature.com
Despite recent advances in understanding skin scarring, mechanisms triggering
hypertrophic scar formation are still poorly understood. In the present study, we investigate …

Collagen Alignment as a Predictor of Recurrence after Ductal Carcinoma In Situ

MW Conklin, RE Gangnon, BL Sprague… - Cancer Epidemiology …, 2018 - aacrjournals.org
Background: Collagen fibers surrounding breast ducts may influence breast cancer
progression. Syndecan-1 interacts with constituents in the extracellular matrix, including …