Memory engrams: Recalling the past and imagining the future

SA Josselyn, S Tonegawa - Science, 2020 - science.org
BACKGROUND The idea that memory is stored as enduring changes in the brain dates
back at least to the time of Plato and Aristotle (circa 350 BCE), but its scientific articulation …

Transcending time in the brain: How event memories are constructed from experience

D Clewett, S DuBrow, L Davachi - Hippocampus, 2019 - Wiley Online Library
Our daily lives unfold continuously, yet when we reflect on the past, we remember those
experiences as distinct and cohesive events. To understand this phenomenon, early …

Predictions transform memories: How expected versus unexpected events are integrated or separated in memory

O Bein, C Gasser, T Amer, A Maril, L Davachi - … & Biobehavioral Reviews, 2023 - Elsevier
Our brains constantly generate predictions about the environment based on prior
knowledge. Many of the events we experience are consistent with these predictions, while …

Memory allocation: mechanisms and function

SA Josselyn, PW Frankland - Annual review of neuroscience, 2018 - annualreviews.org
Memories for events are thought to be represented in sparse, distributed neuronal
ensembles (or engrams). In this article, we review how neurons are chosen to become part …

The brain in motion: How ensemble fluidity drives memory-updating and flexibility

W Mau, ME Hasselmo, DJ Cai - Elife, 2020 - elifesciences.org
While memories are often thought of as flashbacks to a previous experience, they do not
simply conserve veridical representations of the past but must continually integrate new …

Examining memory linking and generalization using scFLARE2, a temporally precise neuronal activity tagging system

JH Jung, Y Wang, AJ Rashid, T Zhang, PW Frankland… - Cell reports, 2023 - cell.com
How memories are organized in the brain influences whether they are remembered
discretely versus linked with other experiences or whether generalized information is …

Brain mechanisms of concept learning

D Zeithamova, ML Mack, K Braunlich, T Davis… - Journal of …, 2019 - jneurosci.org
Concept learning, the ability to extract commonalities and highlight distinctions across a set
of related experiences to build organized knowledge, is a critical aspect of cognition …

Generalization and the hippocampus: More than one story?

D Zeithamova, CR Bowman - Neurobiology of Learning and Memory, 2020 - Elsevier
Memory-based cognition depends on both the ability to remember specific details of
individual experiences and the ability to combine information across experiences to …

Engram mechanisms of memory linking and identity

A Choucry, M Nomoto, K Inokuchi - Nature Reviews Neuroscience, 2024 - nature.com
Memories are thought to be stored in neuronal ensembles referred to as engrams. Studies
have suggested that when two memories occur in quick succession, a proportion of their …

Representations of common event structure in medial temporal lobe and frontoparietal cortex support efficient inference

NW Morton, ML Schlichting, AR Preston - Proceedings of the National …, 2020 - pnas.org
Prior work has shown that the brain represents memories within a cognitive map that
supports inference about connections between individual related events. Real-world …