Evidence indicates that lung cancer development is a complex process that involves
interactions between tumor cells, stromal fibroblasts, and immune cells. Tumor-infiltrating …

Chronic autoimmune diseases, and in particular Systemic Lupus Erythematosus (SLE), are
endowed with a long‐standing autoreactive B‐cell compartment that is presumed to …

It is now well accepted that plasma cells can become long-lived (memory) plasma cells and
secrete antibodies for months, years or a lifetime. However, the mechanisms involved in this …

Aluminum-based adjuvants (aluminum salts or alum) are widely used in human vaccination,
although their mechanisms of action are poorly understood. Here we report that, in mice …

The development of high-affinity B cell memory is regulated through three separable
phases, each involving antigen recognition by specific B cells and cognate T helper cells …

AS03 is an Adjuvant System (AS) containing α-tocopherol and squalene in an oil-in-water
(o/w) emulsion. AS03 has been considered for the development of pandemic and seasonal …

The long-term survival of plasma cells is entirely dependent on signals derived from their
environment. These extrinsic factors presumably induce and sustain the expression of …

Plasma cells are of crucial importance for long-term immune protection. It is thought that long-
lived plasma cells survive in specialized niches in the bone marrow. Here we demonstrate …

The B cell-stimulating molecules, BAFF (B cell activating factor) and APRIL (a proliferation-
inducing ligand), are critical factors in the maintenance of the B cell pool and humoral …

T follicular helper cells (Tfh cells) localize to follicles where they provide growth and
selection signals to mutated germinal center (GC) B cells, thus promoting their differentiation …