The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …

Background In this first-in-human, Phase 1 study of a microRNA-based cancer therapy, the
recommended Phase 2 dose (RP2D) of MRX34, a liposomal mimic of microRNA-34a (miR …

Cancer is a medical condition which has a molecular basis. Proto-oncogenes are the first
regulatory factors of this biological process. They act in transmitting signals, resulting as …

The tumour suppressor gene TP53 is mutated in~ 50% of human cancers. In addition to its
function in tumour suppression, p53 also plays a major role in the response of malignant as …

Lung cancer is the cardinal cause of cancer-related deaths with restricted recourse of
therapy throughout the world. Clinical success of therapies is not very promising due to-late …

MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are …

MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …

Simple Summary The dysregulation of the miR-34 family has been shown to play an
important role in tumorigenesis and cancer progression. In this review, we summarized the …

Recently, a growing number of biological research and scientific experiments have
demonstrated that microRNA (miRNA) affects the development of human complex diseases …