Hypercapnia in COPD: causes, consequences, and therapy
Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder that
may lead to gas exchange abnormalities, including hypercapnia. Chronic hypercapnia is an …
may lead to gas exchange abnormalities, including hypercapnia. Chronic hypercapnia is an …
Carbon dioxide and MAPK signalling: towards therapy for inflammation
H Gałgańska, W Jarmuszkiewicz… - Cell Communication and …, 2023 - Springer
Inflammation, although necessary to fight infections, becomes a threat when it exceeds the
capability of the immune system to control it. In addition, inflammation is a cause and/or …
capability of the immune system to control it. In addition, inflammation is a cause and/or …
Choice of differentiation media significantly impacts cell lineage and response to CFTR modulators in fully differentiated primary cultures of cystic fibrosis human …
In vitro cultures of primary human airway epithelial cells (hAECs) grown at air–liquid
interface have become a valuable tool to study airway biology under normal and pathologic …
interface have become a valuable tool to study airway biology under normal and pathologic …
Molecular mechanisms of Na, K-ATPase dysregulation driving alveolar epithelial barrier failure in severe COVID-19
V Kryvenko, I Vadasz - American Journal of Physiology …, 2021 - journals.physiology.org
A significant number of patients with coronavirus disease 2019 (COVID-19) develop acute
respiratory distress syndrome (ARDS) that is associated with a poor outcome. The molecular …
respiratory distress syndrome (ARDS) that is associated with a poor outcome. The molecular …
Inhibition of the sodium-dependent HCO3-transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype
Bicarbonate secretion is a fundamental process involved in maintaining acid-base
homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in …
homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in …
Maturation of the Na, K-ATPase in the endoplasmic reticulum in health and disease
Abstract The Na, K-ATPase establishes the electrochemical gradient of cells by driving an
active exchange of Na+ and K+ ions while consuming ATP. The minimal functional …
active exchange of Na+ and K+ ions while consuming ATP. The minimal functional …
Spaceflight induced changes in the human proteome
AS Kononikhin, NL Starodubtseva… - Expert Review of …, 2017 - Taylor & Francis
Introduction: Spaceflight is one of the most extreme conditions encountered by humans:
Individuals are exposed to radiation, microgravity, hypodynamia, and will experience …
Individuals are exposed to radiation, microgravity, hypodynamia, and will experience …
Hypercapnia in the critically ill: insights from the bench to the bedside
Carbon dioxide (CO2) has long been considered, at best, a waste by-product of metabolism,
and at worst, a toxic molecule with serious health consequences if physiological …
and at worst, a toxic molecule with serious health consequences if physiological …
Esomeprazole increases airway surface liquid pH in primary cystic fibrosis epithelial cells
Respiratory failure, driven by airways mucus obstruction, chronic inflammation and bacterial
infections, is the main cause of mortality and morbidity in people with cystic fibrosis (CF) due …
infections, is the main cause of mortality and morbidity in people with cystic fibrosis (CF) due …
Hypercapnia induces inositol-requiring enzyme 1α–driven endoplasmic reticulum–associated degradation of the Na, K-ATPase β-subunit
V Kryvenko, M Wessendorf, K Tello… - American Journal of …, 2021 - atsjournals.org
Acute respiratory distress syndrome is often associated with elevated levels of CO2
(hypercapnia) and impaired alveolar fluid clearance. Misfolding of the Na, K-ATPase (NKA) …
(hypercapnia) and impaired alveolar fluid clearance. Misfolding of the Na, K-ATPase (NKA) …