In mammals, erythropoietin (EPO), produced in the kidney, is essential for bone marrow
erythropoiesis, and hypoxia induction of EPO production provides for the important …

Abstract Purpose of Review SARS-CoV-2 drove the catastrophic global phenomenon of the
COVID-19 pandemic resulting in a multitude of systemic health issues, including bone loss …

Abstract Purpose of Review SARS-CoV-2 infection, the culprit of the COVID-19 pandemic,
has been associated with significant long-term effects on various organ systems, including …

To maintain normal cellular and physiological function, sufficient oxygen is required.
Recently, evidence has suggested that hypoxia, either pathological or environmental, may …

Mounting evidence is revealing that heavy metals can incur disordered bone homeostasis,
leading to the development of degenerative bone diseases, including osteoporosis …

Erythropoietin (EPO) primarily regulates red blood cell formation, and EPO serum levels are
increased on hypoxic stress (eg, anemia and altitude). In addition to anemia, recent …

Bone is crucial for the support of muscles and the protection of vital organs, and as a
reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues …

Erythropoietin is essential for bone marrow erythropoiesis and erythropoietin receptor on
non-erythroid cells including bone marrow stromal cells suggests systemic effects of …

Erythropoietin (EPO) is a pleiotropic cytokine that classically drives erythropoiesis but can
also induce bone loss by decreasing bone formation and increasing resorption. Deletion of …

The relationship between the kidney and bone is highly complex, and the kidney plays an
important role in the regulation of bone development and metabolism. The kidney is the …