Alzheimer's disease (AD) is a progressive, mental illness without cure. Several years of
intense research on postmortem AD brains, cell and mouse models of AD have revealed …

Breast cancer is the most prevalent type of cancer among women. Several types of drugs,
targeting the specific proteins expressed on the breast cancer cell surface (such as receptor …

Neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, and
amyotrophic lateral sclerosis, are characterized by a progressive loss of selective neuron …

The human mitochondrial AAA+ protein LONP1 is a critical quality control protease involved
in regulating diverse aspects of mitochondrial biology including proteostasis, electron …

Simple Summary Cannabidiol (CBD) is a phytocannabinoid from Cannabis sativa L. that
exhibits no psychoactivity and, like the psychoactive cannabinoid Δ9-tetrahydrocannabinol …

Background & Aims Mitochondrial dysfunction is considered a pathogenic linker in the
development of non-alcoholic steatohepatitis (NASH). Inappropriate mitochondrial protein …

Mitochondria contain more than 1000 different proteins, including several proteolytic
enzymes. These mitochondrial proteases form a complex system that performs limited and …

Biological aging results from an accumulation of damage in the face of reduced resilience.
One major driver of aging is cell senescence, a state in which cells remain viable but lose …

For its vital role in maintaining cellular activity and survival, mitochondrion is highly involved
in various diseases, and several strategies to target mitochondria have been developed for …

Mitochondrial dysfunction has consequences not only for cellular energy output but also for
cellular signaling pathways. Mitochondrial dysfunction, often based on inherited gene …