Chemical Synthesis of Cell Wall Constituents of Mycobacterium tuberculosis

M Holzheimer, J Buter, AJ Minnaard - Chemical reviews, 2021 - ACS Publications
The pathogen Mycobacterium tuberculosis (Mtb), causing tuberculosis disease, features an
extraordinary thick cell envelope, rich in Mtb-specific lipids, glycolipids, and glycans. These …

Mannose-capped lipoarabinomannan in Mycobacterium tuberculosis pathogenesis

J Turner, JB Torrelles - Pathogens and disease, 2018 - academic.oup.com
Abstract Mannose-capped lipoarabinomannan (ManLAM), present in all members of the
Mycobacterium tuberculosis complex and in other pathogenic Mycobacterium spp, is a high …

Manipulation of the endocytic pathway and phagocyte functions by Mycobacterium tuberculosis lipoarabinomannan

I Vergne, M Gilleron, J Nigou - Frontiers in cellular and infection …, 2015 - frontiersin.org
Lipoarabinomannan is a major immunomodulatory lipoglycan found in the cell envelope of
Mycobacterium tuberculosis and related human pathogens. It reproduces several salient …

Cell walls and membranes of Actinobacteria

KC Rahlwes, IL Sparks, YS Morita - Bacterial Cell Walls and Membranes, 2019 - Springer
Actinobacteria is a group of diverse bacteria. Most species in this class of bacteria are
filamentous aerobes found in soil, including the genus Streptomyces perhaps best known for …

Biomarkers for tuberculosis: the case for lipoarabinomannan

M Correia-Neves, G Fröberg, L Korshun… - ERJ open …, 2019 - publications.ersnet.org
Tuberculosis (TB) is considered the most onerous of infectious diseases according to recent
reports from the World Health Organization. Available tests for TB diagnosis present severe …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2013–2014

DJ Harvey - Mass Spectrometry Reviews, 2018 - Wiley Online Library
This review is the eighth update of the original article published in 1999 on the application of
Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry …

Lipoarabinomannan, and its related glycolipids, induce divergent and opposing immune responses to Mycobacterium tuberculosis depending on structural diversity …

G Källenius, M Correia-Neves, H Buteme, B Hamasur… - Tuberculosis, 2016 - Elsevier
Summary Exposure to Mycobacterium tuberculosis (Mtb) may lead to active or latent
tuberculosis, or clearance of Mtb, depending essentially on the quality of the host's immune …

The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

A Franklin, VC Salgueiro, AJ Layton, R Sullivan… - nature …, 2024 - nature.com
Mycobacterial glycolipids are important cell envelope structures that drive host-pathogen
interactions. Arguably, the most important are lipoarabinomannan (LAM) and its precursor …

Biosynthesis of the Methylthioxylose Cap** Motif of Lipoarabinomannan in Mycobacterium tuberculosis

SK Angala, MR McNeil, L Shi, M Joe, H Pham… - ACS chemical …, 2017 - ACS Publications
Lipoarabinomannan (LAM) is a lipoglycan found in abundant quantities in the cell envelope
of all mycobacteria. The nonreducing arabinan termini of LAM display species-specific …

Polysaccharide Succinylation Enhances the Intracellular Survival of Mycobacterium abscessus

Z Palčeková, M Gilleron, SK Angala… - ACS infectious …, 2020 - ACS Publications
Lipoarabinomannan (LAM) and its biosynthetic precursors, phosphatidylinositol mannosides
(PIMs) and lipomannan (LM) play important roles in the interactions of Mycobacterium …