During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …

Introduction Toxicity data are unavailable for many thousands of chemicals in commerce
and the environment. Therefore, risk assessors need to rapidly screen these chemicals for …

The goal of the present study was to develop an online web-based toolbox that contains
generic physiologically based kinetic (PBK) models for rats and humans, including …

A significant challenge in the traditional human health risk assessment of agrochemicals is
the uncertainty in quantifying the interspecies differences between animal models and …

This external scientific report summarises the results from thearticle 36 grant
GA/EFSA/SCER/2015/01 ″Modelling human variability in toxicokinetic and toxicodynamic …

This study describes the development and intercomparison of generic physiologically-based
toxicokinetic (PBTK) models for humans comprised of internally consistent one-compartment …

In 2017 a large-scale fipronil contamination in eggs occurred in several European countries.
Fipronil and its metabolites have the potential to be transferred into the eggs of laying hens …

In vitro to in vivo extrapolation (IVIVE) leverages in vitro biological activities to predict
corresponding in vivo exposures, therefore potentially reducing the need for animal safety …

Dietary risk assessment of food contaminants requires a well-established understanding of
the exposure in a heterogeneous population. There are many methods for estimating human …

Although there are a number of guidance documents and frameworks for evaluation of
carcinogenicity, none of the current methods fully reflects the state of the science. Common …