Exploring cellular biochemistry with nanobodies
Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …
exploration of biology and in their ultimate application to medicine. Besides ligands for …
Backbone extension acyl rearrangements enable cellular synthesis of proteins with internal β2-peptide linkages
Proteins and polypeptides containing extended backbone monomers embody highly
desirable structures and functions, but they cannot yet be biosynthesized in cells. There are …
desirable structures and functions, but they cannot yet be biosynthesized in cells. There are …
Backbone modifications of HLA-A2-restricted antigens induce diverse binding and T cell activation outcomes
CD8+ T cells express T cell receptors (TCRs) that recognize short peptide antigens in the
context of major histocompatibility class I (MHC I) molecules. This recognition process …
context of major histocompatibility class I (MHC I) molecules. This recognition process …
6‐Strand to Stable 10/12 Helix Conformational Switch by Incorporating Flexible β‐hGly in the Homooligomers of Camphor Derived β‐Amino Acid: NMR and X‐Ray …
Rational design of unnatural amino acid building blocks capable of stabilizing predictable
secondary structures similar to protein fragments is pivotal for foldamer chemistry/catalysis …
secondary structures similar to protein fragments is pivotal for foldamer chemistry/catalysis …
Effects of single α-to-β residue replacements on recognition of an extended segment in a viral fusion protein
Partial replacement of α-amino acid residues with β-amino acid residues has been
established as a strategy for preserving target-engagement by helix-forming polypeptides …
established as a strategy for preserving target-engagement by helix-forming polypeptides …
Proteomimetic surface fragments distinguish targets by function
The fragment-centric design promises a means to develop complex xenobiotic protein
surface mimetics, but it is challenging to find locally biomimetic structures. To address this …
surface mimetics, but it is challenging to find locally biomimetic structures. To address this …
A Study on the Effect of Synthetic α-to-β 3-Amino Acid Mutations on the Binding of Phosphopeptides to 14-3-3 Proteins
Here we describe the synthesis of a series of α, β-phosphopeptides, based on the
phosphoepitope site on YAP1 (yes-associated protein 1), and the biochemical, biophysical …
phosphoepitope site on YAP1 (yes-associated protein 1), and the biochemical, biophysical …
Design Strategies for Protein-Protein Interaction Inhibitors Using Non-Natural Amino Acids
A Tököli - 2023 - search.proquest.com
University of Szeged Faculty of Pharmacy Department of Pharmaceutical Analysis DESIGN
STRATEGIES FOR PROTEIN-PROTEIN INTERACTION Page 1 University of Szeged …
STRATEGIES FOR PROTEIN-PROTEIN INTERACTION Page 1 University of Szeged …
[PDF][PDF] https://www. jbc. org/cgi/doi/10.1074/jbc. REV120. 012960 The latest version is at
RW Cheloha, TJ Harmand, C Wijne, TU Schwartz… - researchgate.net
Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …
exploration of biology and in their ultimate application to medicine. Besides ligands for …