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TGF-β signaling in health, disease and therapeutics
Z Deng, T Fan, C **ao, H Tian, Y Zheng, C Li… - Signal transduction and …, 2024 - nature.com
Transforming growth factor (TGF)-β is a multifunctional cytokine expressed by almost every
tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular …
tissue and cell type. The signal transduction of TGF-β can stimulate diverse cellular …
Regulation of the immune response by TGF-β: from conception to autoimmunity and infection
Transforming growth factor β (TGF-β) is a pleiotropic cytokine involved in both suppressive
and inflammatory immune responses. After 30 years of intense study, we have only begun to …
and inflammatory immune responses. After 30 years of intense study, we have only begun to …
Regulation of immunity during visceral Leishmania infection
Unicellular eukaryotes of the genus Leishmania are collectively responsible for a
heterogeneous group of diseases known as leishmaniasis. The visceral form of …
heterogeneous group of diseases known as leishmaniasis. The visceral form of …
Regulation of immune responses by TGF-β
JJ Letterio, AB Roberts - Annual review of immunology, 1998 - annualreviews.org
▪ Abstract The transforming growth factor β (TGF-β) family of proteins are a set of pleiotropic
secreted signaling molecules with unique and potent immunoregulatory properties. TGF-β1 …
secreted signaling molecules with unique and potent immunoregulatory properties. TGF-β1 …
Thrombospondin-1 is a major activator of TGF-β1 in vivo
The activity of TGF-β1 is regulated primarily extracellularly where the secreted latent form
must be modified to expose the active molecule. Here we show that thrombospondin-1 is …
must be modified to expose the active molecule. Here we show that thrombospondin-1 is …
Regulation and Function of T-Cell-Mediated Immunity during Toxoplasma gondii Infection
The intracellular protozoan Toxoplasma gondii is a widespread opportunistic parasite of
humans and animals. Normally, T. gondii establishes itself within brain and skeletal muscle …
humans and animals. Normally, T. gondii establishes itself within brain and skeletal muscle …
The regulation of immunity to Leishmania major
Experimental infection with the intracellular protozoan Leishmania major constitutes a
particularly versatile model for assessing the role of CD4+ subset development in the host …
particularly versatile model for assessing the role of CD4+ subset development in the host …
Leishmaniases of the New World: current concepts and implications for future research
G Grimaldi Jr, RB Tesh - Clinical microbiology reviews, 1993 - journals.asm.org
Recent epidemiologic studies indicate that leishmaniasis in the Americas is far more
abundant and of greater public health importance than was previously recognized. The …
abundant and of greater public health importance than was previously recognized. The …
Clinical spectrum of leishmaniasis
RD Pearson, A de Queiroz Sousa - Clinical infectious diseases, 1996 - JSTOR
Leishmania species, which are protozoal pathogens belong-ing to the order Kinetoplastida,
have gained increasing notoriety over the past decade as causes of morbidity and mortality …
have gained increasing notoriety over the past decade as causes of morbidity and mortality …
Mechanism of transforming growth factor β–induced inhibition of T helper type 1 differentiation
Regulation by transforming growth factor (TGF)-β plays an important role in immune
homeostasis. TGF-β inhibits T cell functions by blocking both proliferation and differentiation …
homeostasis. TGF-β inhibits T cell functions by blocking both proliferation and differentiation …