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Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
CD4'T cells play a key role in regulating immune system function. When these regulatory
processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau …
processes go awry, organ-specific autoimmune diseases may develop. Here, Roland Liblau …
[HTML][HTML] Insulin-dependent diabetes mellitus
R Tisch, H McDevitt - Cell, 1996 - cell.com
Insulin-dependent diabetes mellitus (IDDM) is a multifactorial autoimmune disease for which
susceptibility is determined by environmental and genetic factors. Inheritance is polygenic …
susceptibility is determined by environmental and genetic factors. Inheritance is polygenic …
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
JJ Lafaille, K Nagashima, M Katsuki, S Tonegawa - Cell, 1994 - cell.com
We have generated TCR transgenic mice (T/R+) specific for myelin basic protein (MBP) and
crossed them to RAG-l-deficient mice to obtain mice (T/R-) that have T cells expressing the …
crossed them to RAG-l-deficient mice to obtain mice (T/R-) that have T cells expressing the …
Genetic control of autoimmune diabetes in the NOD mouse.
The nonobese diabetic (NOD) mouse is a model of human autoimmune insulin-dependent
diabetes mellitus. The NOD mouse also serves as a model for studying complex polygenic …
diabetes mellitus. The NOD mouse also serves as a model for studying complex polygenic …
MHC class II polymorphisms, autoreactive T-cells, and autoimmunity
Major histocompatibility complex (MHC) genes, also known as human leukocyte antigen
genes (HLA) in humans, are the prevailing contributors of genetic susceptibility to …
genes (HLA) in humans, are the prevailing contributors of genetic susceptibility to …
A Structural Framework for Deciphering the Link Between IAg7 and Autoimmune Diabetes
Susceptibility to murine and human insulin-dependent diabetes mellitus correlates strongly
with major histocompatibility complex (MHC) class II IA or HLA-DQ alleles that lack an …
with major histocompatibility complex (MHC) class II IA or HLA-DQ alleles that lack an …
Tolerance to islet autoantigens in type 1 diabetes
JF Bach, L Chatenoud - Annual review of immunology, 2001 - annualreviews.org
Tolerance to β cell autoantigens represents a fragile equilibrium. Autoreactive T cells
specific to these autoantigens are present in most normal individuals but are kept under …
specific to these autoantigens are present in most normal individuals but are kept under …
Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice.
L Wogensen, MS Lee, N Sarvetnick - The Journal of experimental …, 1994 - rupress.org
The T helper type 2 (Th2) cell product interleukin 10 (IL-10) inhibits the proliferation and
function of Th1 lymphocytes and macrophages (M phi). The nonobese diabetic mouse strain …
function of Th1 lymphocytes and macrophages (M phi). The nonobese diabetic mouse strain …
A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins
In human type 1 diabetes (T1D) and in its murine model, the major histocompatibility
complex (MHC) class II molecules, human leukocyte antigens (HLA)-DQ and-DR and their …
complex (MHC) class II molecules, human leukocyte antigens (HLA)-DQ and-DR and their …
A mechanism for the major histocompatibility complex–linked resistance to autoimmunity
D Schmidt, J Verdaguer, N Averill… - The Journal of …, 1997 - rupress.org
Certain major histocompatibility complex (MHC) class II haplotypes encode elements
providing either susceptibility or dominant resistance to the development of spontaneous …
providing either susceptibility or dominant resistance to the development of spontaneous …