Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene
transcription. It is generally accepted that E–TC makes a crucial contribution to learning and …

Ca2+/calmodulin-dependent protein kinase kinase (CaMKK) is the activating kinase for
multiple downstream kinases, including CaM-kinase I (CaMKI), CaM-kinase IV (CaMKIV) …

Caenorhabditis elegans lives in a complex habitat in which they routinely experience large
fluctuations in temperature, and encounter physical obstacles that vary in size and …

Properly functional CNS circuits depend on inhibitory interneurons that in turn rely upon
activity-dependent gene expression for morphological development, connectivity, and …

Animals rely on their nervous systems to process sensory inputs, integrate these with
internal signals, and produce behavioral outputs. This is enabled by the highly specialized …

Critical to evolutionary fitness, animals regulate social behaviors by integrating signals from
both their external environments and internal states. Here, we find that population density …

Neurons modify their transcriptomes in response to an animal's experience. How specific
experiences are transduced to modulate gene expression and precisely tune neuronal …

Unveiling the molecular and cellular mechanisms underlying memory has been a challenge
for the past few decades. Although synaptic plasticity is proven to be essential for memory …

Neural plasticity, the ability of neurons to change their properties in response to
experiences, underpins the nervous system's capacity to form memories and actuate …

Soil-transmitted parasitic nematodes infect over one billion people and cause devastating
morbidity worldwide. Many of these parasites have infective larvae that locate hosts using …