Understanding sorafenib-induced ferroptosis and resistance mechanisms: Implications for cancer therapy

Q Li, K Chen, T Zhang, D Jiang, L Chen, J Jiang… - European Journal of …, 2023 - Elsevier
Sorafenib is an important first-line treatment option for liver cancer due to its well-
characterized safety profile. While novel first-line drugs may have better efficacy than …

Current progress of ferroptosis study in hepatocellular carcinoma

X Zhu, X Sha, Y Zang, Q Ren, S Zhang… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Ferroptosis, an emerging type of programmed cell death, is initiated by iron-dependent and
excessive ROS-mediated lipid peroxidation, which eventually leads to plasma membrane …

The role of Nrf2 in the regulation of mitochondrial function and ferroptosis in pancreatic cancer

D Baiskhanova, H Schäfer - Antioxidants, 2024 - mdpi.com
The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) represents the
master regulator of the cellular antioxidant response and plays a critical role in …

Ferroptosis in liver disease: Natural active compounds and therapeutic implications

Z Wu, Y Zhu, W Liu, B Balasubramanian, X Xu, J Yao… - Antioxidants, 2024 - mdpi.com
Ferroptosis is an emerging type of regulated cell death usually accompanied by the
accumulation of ferrous ions (Fe2+) and lipid peroxides. As the metabolic hub of the body …

Ferroptosis: a new promising target for hepatocellular carcinoma therapy

Q Xu, L Ren, N Ren, Y Yang, J Pan, Y Zheng… - Molecular and Cellular …, 2024 - Springer
Hepatocellular carcinoma (HCC) is the sixed most common malignant tumor in the world.
The study for HCC is mired in the predicament confronted with the difficulty of early …

[HTML][HTML] The application of alkaloids in ferroptosis: A review

B Fan, Q Guo, S Wang - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Alkaloids have remarkable biological and pharmacological properties and have recently
garnered extensive attention. Various alkaloids, including commercially available drugs …

Dual role of Nrf2 signaling in hepatocellular carcinoma: promoting development, immune evasion, and therapeutic challenges

L Gan, W Wang, J Jiang, K Tian, W Liu… - Frontiers in …, 2024 - frontiersin.org
Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and ranks as the
third leading cause of cancer-related mortality globally. The liver performs a wide range of …

SLC7A11 in hepatocellular carcinoma: Potential mechanisms, regulation, and clinical significance

T Li, J Yi, H Wu, K Wang, B Zhou - American Journal of Cancer …, 2024 - pmc.ncbi.nlm.nih.gov
Exploring novel early detection biomarkers and develo** more efficacious treatments
remain pressing tasks in the current research landscape for hepatocellular carcinoma …

Pharmacokinetics–Pharmacodynamics Modeling for Evaluating Drug–Drug Interactions in Polypharmacy: Development and Challenges

D Zhao, P Huang, L Yu, Y He - Clinical Pharmacokinetics, 2024 - Springer
Polypharmacy is commonly employed in clinical settings. The potential risks of drug–drug
interactions (DDIs) can compromise efficacy and pose serious health hazards. Integrating …

[HTML][HTML] Camrelizumab combined with transcatheter arterial chemoembolization and sorafenib or lenvatinib for unresectable hepatocellular carcinoma: A multicenter …

X Jiang, P Wang, K Su, H Li, H Chi, F Wang, Y Liu… - Annals of …, 2025 - Elsevier
Abstract Introduction and Objectives We initiated this study to explore the efficacy of
camrelizumab combined with transcatheter arterial chemoembolization (TACE) plus …