[HTML][HTML] Simulation-based approaches for drug delivery systems: Navigating advancements, opportunities, and challenges

I Salahshoori, M Golriz, MAL Nobre, S Mahdavi… - Journal of Molecular …, 2024 - Elsevier
Efficient drug delivery systems (DDSs) play a pivotal role in ensuring pharmaceuticals'
targeted and effective administration. However, the intricate interplay between drug …

Mathematical modeling of release kinetics from supramolecular drug delivery systems

C Mircioiu, V Voicu, V Anuta, A Tudose, C Celia… - Pharmaceutics, 2019 - mdpi.com
Embedding of active substances in supramolecular systems has as the main goal to ensure
the controlled release of the active ingredients. Whatever the final architecture or entrapment …

Comparative statistical analysis of the release kinetics models for nanoprecipitated drug delivery systems based on poly (lactic-co-glycolic acid)

NS Heredia, K Vizuete, M Flores-Calero, K Pazmiño V… - PLoS …, 2022 - journals.plos.org
Poly (lactic-co-glycolic acid) is one of the most used polymers for drug delivery systems
(DDSs). It shows excellent biocompatibility, biodegradability, and allows spatio-temporal …

Mathematical models in drug delivery: How modeling has shaped the way we design new drug delivery systems

NA Peppas, B Narasimhan - Journal of Controlled Release, 2014 - Elsevier
In this review we present some of the seminal contributions that have established the
mathematical foundations of controlled drug delivery and led to the modern models …

Drug carriers: A review on the most used mathematical models for drug release

P Trucillo - Processes, 2022 - mdpi.com
Carriers are protective transporters of drugs to target cells, facilitating therapy under each
points of view, such as fast healing, reducing infective phenomena, and curing illnesses …

In vitro release kinetics model fitting of liposomes: An insight

A Jain, SK Jain - Chemistry and physics of lipids, 2016 - Elsevier
Liposomes are emerging cargoes for bioactive delivery owing to their widely accepted
biocompatible and biodegradable nature. It is always a challenge to control the release of …

On the use of the Weibull function for the discernment of drug release mechanisms

V Papadopoulou, K Kosmidis, M Vlachou… - International journal of …, 2006 - Elsevier
Previous findings from our group based on Monte Carlo simulations indicated that Fickian
drug release from Euclidian or fractal matrices can be described with the Weibull function. In …

A century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system

A Dokoumetzidis, P Macheras - International journal of pharmaceutics, 2006 - Elsevier
Dissolution research started to develop about 100 years ago as a field of physical chemistry
and since then important progress has been made. However, explicit interest in drug related …

The use of hypromellose in oral drug delivery

CL Li, LG Martini, JL Ford… - Journal of pharmacy and …, 2005 - Wiley Online Library
Hypromellose, formerly known as hydroxypropylmethylcellulose (HPMC), is by far the most
commonly employed cellulose ether used in the fabrication of hydrophilic matrices …

Elaborations on the Higuchi model for drug delivery

DR Paul - International journal of pharmaceutics, 2011 - Elsevier
The Higuchi model for the rate of drug release from matrix devices where the drug loading
exceeds the solubility in the matrix medium, whose 50-year anniversary is celebrated in this …