Liquid chromatography–tandem mass spectrometry for clinical diagnostics

SN Thomas, D French, PJ Jannetto… - Nature Reviews …, 2022 - nature.com
Mass spectrometry is a powerful analytical tool used for the analysis of a wide range of
substances and matrices; it is increasingly utilized for clinical applications in laboratory …

Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

LM Butler, Y Perone, J Dehairs, LE Lupien… - Advanced drug delivery …, 2020 - Elsevier
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Mass spectrometry-based proteomics as an emerging tool in clinical laboratories

AG Birhanu - Clinical proteomics, 2023 - Springer
Mass spectrometry (MS)-based proteomics have been increasingly implemented in various
disciplines of laboratory medicine to identify and quantify biomolecules in a variety of …

Emerging applications of metabolomics in drug discovery and precision medicine

DS Wishart - Nature reviews Drug discovery, 2016 - nature.com
Metabolomics is an emerging'omics' science involving the comprehensive characterization
of metabolites and metabolism in biological systems. Recent advances in metabolomics …

Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system

J Zhang, J Rector, JQ Lin, JH Young, M Sans… - Science translational …, 2017 - science.org
Conventional methods for histopathologic tissue diagnosis are labor-and time-intensive and
can delay decision-making during diagnostic and therapeutic procedures. We report the …

Spatially resolved metabolomics to discover tumor-associated metabolic alterations

C Sun, T Li, X Song, L Huang, Q Zang, J Xu… - Proceedings of the …, 2019 - pnas.org
Characterization of tumor metabolism with spatial information contributes to our
understanding of complex cancer metabolic reprogramming, facilitating the discovery of …

Molecular networking as a drug discovery, drug metabolism, and precision medicine strategy

RA Quinn, LF Nothias, O Vining, M Meehan… - Trends in …, 2017 - cell.com
Molecular networking is a tandem mass spectrometry (MS/MS) data organizational
approach that has been recently introduced in the drug discovery, metabolomics, and …

Overview of mass spectrometry-based metabolomics: opportunities and challenges

GAN Gowda, D Djukovic - Mass spectrometry in metabolomics: methods …, 2014 - Springer
The field of metabolomics has witnessed an exponential growth in the last decade driven by
important applications spanning a wide range of areas in the basic and life sciences and …

Rapid evaporative ionisation mass spectrometry of electrosurgical vapours for the identification of breast pathology: towards an intelligent knife for breast cancer …

ER St John, J Balog, JS McKenzie, M Rossi… - Breast Cancer …, 2017 - Springer
Background Re-operation for positive resection margins following breast-conserving surgery
occurs frequently (average= 20–25%), is cost-inefficient, and leads to physical and …