An overview of cannabidiol as a multifunctional drug: pharmacokinetics and cellular effects

N Martinez Naya, J Kelly, G Corna, M Golino… - Molecules, 2024 - mdpi.com
Cannabidiol (CBD), a non-psychoactive compound derived from Cannabis Sativa, has
garnered increasing attention for its diverse therapeutic potential. This comprehensive …

Cannabidiol and neurodegeneration: From molecular mechanisms to clinical benefits

SK Jha, VK Nelson, PR Suryadevara, SP Panda… - Ageing research …, 2024 - Elsevier
Neurodegenerative disorders (NDs) such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis are severe and …

Anti-cancer and anti-proliferative potential of cannabidiol: A cellular and molecular perspective

MD Mashabela, AP Kappo - International journal of molecular sciences, 2024 - mdpi.com
Cannabinoids, the bioactive compounds found in Cannabis sativa, have been used for
medicinal purposes for centuries, with early discoveries dating back to the BC era (BCE) …

Novel Therapeutics and Upcoming Clinical Trials Targeting Inflammation in Cardiovascular Diseases

N Potere, A Bonaventura, A Abbate - … , Thrombosis, and Vascular …, 2024 - ahajournals.org
Cardiovascular disease (CVD) remains a major health burden despite significant
therapeutic advances accomplished over the last decades. It is widely and increasingly …

[HTML][HTML] Anxiety Modulation by cannabinoids—The role of stress responses and co**

J Haller - International Journal of Molecular Sciences, 2023 - mdpi.com
Endocannabinoids were implicated in a variety of pathological conditions including anxiety
and are considered promising new targets for anxiolytic drug development. The optimism …

The NLRP3 inflammasome: A vital player in inflammation and mediating the anti-inflammatory effect of CBD

F Chu, X Wang, B Li, L Xu, B Di - Inflammation Research, 2024 - Springer
Background The NLRP3 inflammasome is a vital player in the emergence of inflammation.
The priming and activation of the NLRP3 inflammasome is a major trigger for inflammation …

Cannabidiol exerts multitarget immunomodulatory effects on PBMCs from individuals with psoriasis vulgaris

C Pagano, E Ciaglia, L Coppola, V Lopardo… - Frontiers in …, 2024 - frontiersin.org
Introduction The involvement of endocannabinoid system (ECS) in the inflammatory
cascade, and the ability of phytocannabinoids, endocannabinoids and their synthetic …

[HTML][HTML] Putative role of immune reactions in the mechanism of tardive dyskinesia

AJM Loonen - Brain, Behavior, & Immunity-Health, 2023 - Elsevier
The term extrapyramidal disorders is most often used for conditions such as Parkinson's
disease or Huntington's disease, but also refers to a group of extrapyramidal side effects of …

[HTML][HTML] The Antioxidant and Neuroprotective Potential of Leaves and Inflorescences Extracts of Selected Hemp Varieties Obtained with scCO2

A Stasiłowicz-Krzemień, S Sip, P Szulc, J Walkowiak… - Antioxidants, 2023 - mdpi.com
Cannabis sativa, a versatile plant with numerous varieties, holds promising potential for a
wide range of biological activity. As raw materials for research, we chose leaves and …

The renoprotective effects of cannabidiol on lipopolysaccharide-induced systemic inflammation model of rats

İ İlhan, H Asci, O Ozmen, Hİ Buyukbayram… - Naunyn-Schmiedeberg's …, 2024 - Springer
Sepsis-induced renal damage poses a significant threat, necessitating effective therapeutic
strategies. Cannabidiol (CBD) has beneficial effects on tissues and their functions by …