The global pandemic of obesity and type 2 diabetes is often causally linked to marked
changes in diet and lifestyle; namely marked increases in dietary intakes of high energy …

Choline influences liver function, and the dietary requirement for this nutrient varies
depending on an individual's genotype and estrogen status. Understanding these individual …

Prenatal famine in humans has been associated with various later-life consequences,
depending on the gestational timing of the insult and the sex of the exposed individual …

Leptin is an adipocyte-secreted hormone that inhibits food intake and stimulates energy
expenditure through interactions with neuronal pathways in the brain, particularly pathways …

The obesity epidemic is a global issue and shows no signs of abating, while the cause of
this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally …

Although genetics determines endocrine phenotypes, it cannot fully explain the great
variability and reversibility of the system in response to environmental changes. Evidence …

In recent years, we've developed a much better grasp of the biological and other factors
associated with the development of obesity. Reflecting our evolving understanding of …

Excessive weight gain arises from the interactions among environmental factors, genetic
predisposition and the individual behavior. However, it is becoming evident that …

The incidence of obesity and overweight has reached epidemic proportions in the
developed world as well as in those countries transitioning to first world economies, and this …

Leptin is an adipokine involved in body weight and food intake regulation whose promoter
region presents CpG islands that could be subject to dynamic methylation. This methylation …