Neuropsychiatric conditions represent a major medical and societal challenge. The etiology
of these conditions is very complex and combines genetic and environmental factors. The …

The failure rate of drugs being developed for neuropsychiatric indications remains high.
Optimizing drug discovery and development requires not only a better neurobiological …

Increasing evidence points toward the role of the extracellular matrix, specifically matrix
metalloproteinase 9 (MMP-9), in the pathophysiology of psychosis. MMP-9 is a critical …

Background Accumulating evidence has indicated that oxidative stress (OS) and matrix
metalloproteinase-9 (MMP-9) may contribute to the mechanism of schizophrenia. In the …

Background While the molecular underpinnings of vascular dysfunction in psychosis are
under active investigation, their implications remain unclear due to inconsistent and …

Ischemic stroke is a leading cause of disability worldwide. While much of post-stroke
recovery is focused on physical rehabilitation, post-stroke dementia (PSD) is also a …

Inflammation and an exacerbated immune response are widely accepted contributing
mechanisms to the genesis and progression of major neuropsychiatric disorders. However …

Background Converging evidence supports the role of Matrix Metalloproteinases (MMPs) in
psychiatric disorders. Originally identified as regulators of the extracellular matrix (ECM) …

Ischaemic stroke characterises impulsive cerebral-region hypoxia due to deep intracerebral
arteriole blockage, often accompanied by permanent cerebral infarction and cognitive …

Schizophrenia is a devastating psychiatric disorder that has detrimental effects on a
significant portion of the global population. Electroconvulsive therapy (ECT), as a safe and …