Cancer is a heterogeneous disease caused by diverse genomic alterations in oncogenes
and tumor suppressor genes. Despite recent advances in high-throughput sequencing …

Gastric cancer (GC) remains the third most common cause of cancer death worldwide, with
limited therapeutic strategies available. With the advent of next-generation sequencing and …

Chemoresistance remains the major obstacle to achieve optimal prognosis in gastric cancer
patients, and the underlying molecular mechanisms of cancer-associated fibroblasts (CAFs) …

Gastric cancer is among the most common malignancies worldwide, characterized by
geographical, epidemiological and histological heterogeneity. Here, we report an extensive …

Background Lycorine hydrochloride (LH), an alkaloid extracted from the bulb of the Lycoris
radiata, is considered to have anti-viral, anti-malarial, and anti-tumorous effects. At present …

Gastric cancer (GC) is a common malignant neoplasm worldwide and one of the main cause
of cancer-related deaths. Despite some advances in therapies, long-term survival of patients …

Humanized mice are superior to rodents for preclinical evaluation of the efficacy and safety
of drug candidates using human cells or tissues. During the past decade, humanized mouse …

RHO GTPases have been traditionally associated with protumorigenic functions. While this
paradigm is still valid in many cases, recent data have unexpectedly revealed that RHO …

Background Gastric cancer (GC) is one of the leading causes of cancer deaths with high
heterogeneity. There is currently a paucity of clinically applicable molecular classification …

Tumor-promoting inflammation is a hallmark of cancer and is highly associated with tumor
progression, angiogenesis, and metastasis. Tumor-associated macrophages (TAMs) are …