The potential to generate virtually any differentiated cell type from embryonic stem cells
(ESCs) offers the possibility to establish new models of mammalian development and to …

Long non-coding RNAs (lncRNAs) have gained great attention as epigenetic regulators of
gene expression in many tissues. Increasing evidence indicates that lncRNAs, together with …

Human pluripotent stem cells (hPSCs) offer the potential to generate large numbers of
functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that …

Mouse embryonic stem cells (mESCs) are clonal populations derived from preimplantation
mouse embryos that can be propagated in vitro and, when placed into blastocysts …

Efficient differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells
(iPSCs) to a variety of lineages requires step-wise approaches replicating the key …

Stem cell therapy for cardiac disease is an exciting but highly controversial research area.
Strategies such as cell transplantation and reprogramming have demonstrated both …

Cardiogenesis requires the generation of endothelial, cardiac, and smooth muscle cells,
thought to arise from distinct embryonic precursors. We use genetic fate-map** studies to …

Pluripotent embryonic stem (ES) cells must select between alternative fates of self-
replication and lineage commitment during continuous proliferation. Here, we delineate the …

The mammalian heart is a highly specialized organ, comprised of many different cell types
arising from distinct embryonic progenitor populations during cardiogenesis. Three …

Understanding heart development on a molecular level is a prerequisite for uncovering the
causes of congenital heart diseases. Therapeutic approaches that try to enhance cardiac …