Background Doxorubicin (DOX) is a widely utilized anthracycline chemotherapy drug in
cancer treatment, yet its efficacy is hindered by both short-term and long-term cardiotoxicity …

Sirtuin 6 (SIRT6) is a member of the mammalian sirtuin family of NAD+-dependent protein
deacylases, homologues of the yeast silent information regulator 2 (Sir2). SIRT6 has …

Background: Redox homeostasis is the vital regulatory system with respect to antioxidative
response and detoxification. The imbalance of redox homeostasis causes oxidative stress …

Cardiovascular diseases are severe diseases posing threat to human health because of
their high morbidity and mortality worldwide. The incidence of diabetes mellitus is also …

More than a century after the discovery of nicotinamide adenine dinucleotide (NAD+), our
understanding of the molecule's role in the biology of ageing continues to evolve. As a …

Hearing loss is a health crisis that affects more than 60 million Americans. Currently, sodium
thiosulfate is the only drug approved by the Food and Drug Administration (FDA) to counter …

Oxidative stress is a physiological condition that arises when there is an imbalance between
the production of reactive oxygen species (ROS) and the ability of cells to neutralize them …

目的优化沙丁鱼(Sardina pilchardus) 鱼鳞胶原蛋白肽的制备工艺和评价不同分子量大小胶原
蛋白肽的抗氧化活性. 方法以沙丁鱼鱼鳞为原料, 通过酶工程结合单因素与响应面实验优化胶原 …

Radiation-induced liver disease (RILD), also known as radiation hepatitis, is subacute liver
injury induced by radiation. As the focus of senescence-related studies, the deacetylase …

Cholestatic liver disease, caused by accumulation of hazardous bile acids in the liver, may
result in cirrhosis, fibrosis, or liver failure. Activation of Sirt6 prevents cholestasis-associated …