Chondrocytes are the main cell type in articular cartilage. They are embedded in an
avascular, abundant, and specialized extracellular matrix (ECM). Chondrocytes are …

The gene of transcriptional repressor GATA binding 1 (TRPS1), as an atypical GATA
transcription factor, has received considerable attention in a plethora of physiological and …

Skin color is highly variable in Africans, yet little is known about the underlying molecular
mechanism. Here we applied massively parallel reporter assays to screen 1,157 candidate …

TRPS1 has been recently demonstrated as a highly sensitive and specific marker for breast
carcinomas. To further explore TRPS1's utility in breast carcinoma, we systematically …

Osteosarcoma (OS) is an aggressive bone tumor that originates from mesenchymal cells. It
is considered as the eighth most frequent childhood cancer that mainly affects the tibia and …

Multiple myeloma (MM) is a common hematological malignancy arising from terminally
differentiated plasma cells. In the majority of cases, symptomatic disease is characterized by …

Objectives TRPS1 is a new, sensitive marker for breast carcinoma (BC). Salivary glands and
breasts are both exocrine glands; thus, their tumors may share similar morphology and …

Myeloma bone disease is a devastating complication of multiple myeloma (MM) and is
caused by dysregulation of bone remodeling processes in the bone marrow …

Background As syndromic short stature and overgrowth are heterogeneous and the list of
causative genes is rapidly expanding, there is an unmet need for identifying genetic causes …

Background Transcriptional repressor GATA binding 1 (TRPS1) is a transcription factor
recently shown to play a role in the development of breast and liver cancer. Here, we …