Basket trials in oncology: a systematic review of practices and methods, comparative analysis of innovative methods, and an appraisal of a missed opportunity
A Kasim, N Bean, SJ Hendriksen, TT Chen… - Frontiers in …, 2023 - frontiersin.org
Background Basket trials are increasingly used in oncology drug development for early
signal detection, accelerated tumor-agnostic approvals, and prioritization of promising tumor …
signal detection, accelerated tumor-agnostic approvals, and prioritization of promising tumor …
A comparison of Bayesian information borrowing methods in basket trials and a novel proposal of modified exchangeability‐nonexchangeability method
Recent innovation in trial design to improve study efficiency has led to the development of
basket trials in which a single therapeutic treatment is tested on several patient populations …
basket trials in which a single therapeutic treatment is tested on several patient populations …
Bayesian modelling strategies for borrowing of information in randomised basket trials
Basket trials are an innovative precision medicine clinical trial design evaluating a single
targeted therapy across multiple diseases that share a common characteristic. To date, most …
targeted therapy across multiple diseases that share a common characteristic. To date, most …
Categories, components, and techniques in a modular construction of basket trials for application and further research
M Pohl, J Krisam, M Kieser - Biometrical Journal, 2021 - Wiley Online Library
Basket trials have become a virulent topic in medical and statistical research during the last
decade. The core idea of them is to treat patients, who express the same genetic …
decade. The core idea of them is to treat patients, who express the same genetic …
Bayesian and frequentist approaches to sequential monitoring for futility in oncology basket trials: A comparison of Simon's two-stage design and Bayesian predictive …
This article discusses and compares statistical designs of basket trial, from both frequentist
and Bayesian perspectives. Baskets trials are used in oncology to study interventions that …
and Bayesian perspectives. Baskets trials are used in oncology to study interventions that …
A frequentist design for basket trials using adaptive lasso
A basket trial aims to expedite the drug development process by evaluating a new therapy in
multiple populations within the same clinical trial. Each population, referred to as a “basket” …
multiple populations within the same clinical trial. Each population, referred to as a “basket” …
A basket trial design based on power priors
L Baumann, LD Sauer, M Kieser - Statistics in Biopharmaceutical …, 2024 - Taylor & Francis
In basket trials a treatment is investigated in several subgroups. They are primarily used in
oncology in early clinical phases as single-arm trials with a binary endpoint. For their …
oncology in early clinical phases as single-arm trials with a binary endpoint. For their …
Frequentist analysis of basket trials with one‐sample Mantel‐Haenszel procedures
S Hattori, S Morita - Statistics in Medicine, 2023 - Wiley Online Library
Recent substantial advances of molecular targeted oncology drug development is requiring
new paradigms for early‐phase clinical trial methodologies to enable us to evaluate efficacy …
new paradigms for early‐phase clinical trial methodologies to enable us to evaluate efficacy …
Dose Individualization for Phase I Cancer Trials With Broadened Eligibility
RB Silva, B Cheng, RD Carvajal… - Statistics in Medicine, 2024 - Wiley Online Library
Broadening eligibility criteria in cancer trials has been advocated to represent the intended
patient population more accurately. The advantages are clear in terms of generalizability …
patient population more accurately. The advantages are clear in terms of generalizability …
Bayesian Methods for Information Borrowing in Basket Trials: An Overview
Simple Summary This paper provides a review of statistical methods for tumor-agnostic
clinical trials. In particular, the review focuses on basket trials and provides methodological …
clinical trials. In particular, the review focuses on basket trials and provides methodological …