The centrosome is the main microtubule (MT)-organizing centre of animal cells. It consists of
two centrioles and a multi-layered proteinaceous structure that surrounds the centrioles, the …

Limited DNA end resection is the key to impaired homologous recombination in BRCA1-
mutant cancer cells. Here, using a loss-of-function CRISPR screen, we identify DYNLL1 as …

In textbooks, the mitotic spindles of plants are often described separately from those of
animals. How do they differ at the molecular and mechanistic levels? In this chapter, we first …

Despite extensive studies on mammalian neurogenesis, its post-transcriptional regulation
remains under-explored. Here we report that neural-specific inactivation of two murine post …

Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis.
However, the composition of transported ribonucleoprotein particles (RNPs) and the …

Cytoplasmic dynein is responsible for a wide range of cellular roles. How this single motor
protein performs so many functions has remained a major outstanding question for many …

The microtubule motor dynein plays a key role in cellular organization. However, little is
known about how dynein's biosynthesis, assembly, and functional diversity are orchestrated …

Abstract The Tousled-like kinases (TLKs) are an evolutionarily conserved family of serine–
threonine kinases that have been implicated in DNA replication, DNA repair, transcription …

The cytoplasmic dynein motor generates pulling forces to center and orient the mitotic
spindle within the cell. During this positioning process, dynein oscillates from one pole of the …

In animal gonads, the PIWI-interacting RNA (piRNA) pathway guards genome integrity in
part through the co-transcriptional gene silencing of transposon insertions. In Drosophila …