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Inhibition of GSK3 by lithium, from single molecules to signaling networks
For more than 60 years, the mood stabilizer lithium has been used alone or in combination
for the treatment of bipolar disorder, schizophrenia, depression, and other mental illnesses …
for the treatment of bipolar disorder, schizophrenia, depression, and other mental illnesses …
Schizophrenia in a genomic era: a review from the pathogenesis, genetic and environmental etiology to diagnosis and treatment insights
Schizophrenia is a common multigenic and debilitating neurological disorder characterized
by chronic psychotic symptoms and psychosocial impairment. Complex interactions of …
by chronic psychotic symptoms and psychosocial impairment. Complex interactions of …
Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users
BACKGROUND: Cannabis use is associated with an increased risk of psychosis. One study
has suggested that genetic variation in the AKT1 gene might influence this effect …
has suggested that genetic variation in the AKT1 gene might influence this effect …
The DRD2 antagonist haloperidol mediates autophagy-induced ferroptosis to increase temozolomide sensitivity by promoting endoplasmic reticulum stress in …
L Shi, H Chen, K Chen, C Zhong, C Song… - Clinical Cancer …, 2023 - aacrjournals.org
Purpose: Temozolomide resistance remains a major obstacle in the treatment of
glioblastoma (GBM). The combination of temozolomide with another agent could offer an …
glioblastoma (GBM). The combination of temozolomide with another agent could offer an …
Beyond cAMP: the regulation of Akt and GSK3 by dopamine receptors
Brain dopamine receptors have been preferred targets for numerous pharmacological
compounds developed for the treatment of various neuropsychiatric disorders. Recent …
compounds developed for the treatment of various neuropsychiatric disorders. Recent …
Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments
G Bartzokis - Neuropharmacology, 2012 - Elsevier
Current psychiatric diagnostic schema segregate symptom clusters into discrete entities,
however, large proportions of patients suffer from comorbid conditions that fit neither …
however, large proportions of patients suffer from comorbid conditions that fit neither …
Interaction between functional genetic variation of DRD2 and cannabis use on risk of psychosis
Both cannabis use and the dopamine receptor (DRD2) gene have been associated with
schizophrenia, psychosis-like experiences, and cognition. However, there are no published …
schizophrenia, psychosis-like experiences, and cognition. However, there are no published …
Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies
BackgroundThe hypothesis that cortical dopaminergic alterations underlie aspects of
schizophrenia has been highly influential. AimsTo bring together and evaluate the imaging …
schizophrenia has been highly influential. AimsTo bring together and evaluate the imaging …
Antipsychotic drug responsiveness and dopamine receptor signaling; old players and new prospects
A Rampino, A Marakhovskaia, T Soares-Silva… - Frontiers in …, 2019 - frontiersin.org
Antipsychotic drugs targeting dopamine neurotransmission are still the principal mean of
therapeutic intervention for schizophrenia. However, about one third of people do not …
therapeutic intervention for schizophrenia. However, about one third of people do not …
Treatment-resistant schizophrenia: genetic and neuroimaging correlates
Schizophrenia is a severe neuropsychiatric disorder that affects approximately 0.5–1% of
the population. Response to antipsychotic therapy is highly variable, and it is not currently …
the population. Response to antipsychotic therapy is highly variable, and it is not currently …