Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson's disease

B de Laat, J Hoye, G Stanley, M Hespeler, J Ligi… - npj Parkinson's …, 2024 - nature.com
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons.
Exercise has been reported to slow the clinical progression of PD. We evaluated the …

R2* and quantitative susceptibility map** in deep gray matter of 498 healthy controls from 5 to 90 years

S Treit, N Naji, P Seres, J Rickard, E Stolz… - Human Brain …, 2021 - Wiley Online Library
Putative MRI markers of iron in deep gray matter have demonstrated age related changes
during discrete periods of healthy childhood or adulthood, but few studies have included …

[HTML][HTML] The traveling heads 2.0: multicenter reproducibility of quantitative imaging methods at 7 Tesla

MN Voelker, O Kraff, S Goerke, FB Laun, J Hanspach… - Neuroimage, 2021 - Elsevier
Object This study evaluates inter-site and intra-site reproducibility at ten different 7 T sites for
quantitative brain imaging. Material and Methods Two subjects–termed the “traveling heads” …

The sequence of regional structural disconnectivity due to multiple sclerosis lesions

C Tozlu, E Olafson, KW Jamison… - Brain …, 2023 - academic.oup.com
Prediction of disease progression is challenging in multiple sclerosis as the sequence of
lesion development and retention of inflammation within a subset of chronic lesions is …

[HTML][HTML] Multi-centre, multi-vendor reproducibility of 7T QSM and R2* in the human brain: Results from the UK7T study

C Rua, WT Clarke, ID Driver, O Mougin, AT Morgan… - Neuroimage, 2020 - Elsevier
Introduction We present the reliability of ultra-high field T 2* MRI at 7T, as part of the UK7T
Network's “Travelling Heads” study. T 2*-weighted MRI images can be processed to produce …

Quantitative susceptibility map**: MRI at 7T versus 3T

P Spincemaille, J Anderson, G Wu… - Journal of …, 2020 - Wiley Online Library
ABSTRACT BACKGROUND AND PURPOSE Ultrahigh‐field 7T promises more than
doubling the signal‐to‐noise ratio (SNR) of 3T for magnetic resonance imaging (MRI) …

Initial experience of challenge-free MRI-based oxygen extraction fraction map** of ischemic stroke at various stages: comparison with perfusion and diffusion …

S Zhang, J Cho, TD Nguyen, P Spincemaille… - Frontiers in …, 2020 - frontiersin.org
MRI-based oxygen extraction fraction imaging has a great potential benefit in the selection
of clinical strategies for ischemic stroke patients. This study aimed to evaluate the …

Structural disconnectivity from paramagnetic rim lesions is related to disability in multiple sclerosis

C Tozlu, K Jamison, T Nguyen, N Zinger… - Brain and …, 2021 - Wiley Online Library
Background In people with multiple sclerosis (pwMS), lesions with a hyperintense rim (rim+)
on Quantitative Susceptibility Map** (QSM) have been shown to have greater myelin …

[HTML][HTML] Ironsmith: an automated pipeline for QSM-based data analyses

V Zachariou, CE Bauer, DK Powell, BT Gold - Neuroimage, 2022 - Elsevier
Quantitative susceptibility map** (QSM) is an MRI-based, computational method for
anatomically localizing and measuring concentrations of specific biomarkers in tissue such …

Brain oxygen extraction and neural tissue susceptibility are associated with cognitive impairment in older individuals

GC Chiang, J Cho, J Dyke, H Zhang… - Journal of …, 2022 - Wiley Online Library
Abstract Background and Purpose We investigated the effects of aging, white matter
hyperintensities (WMH), and cognitive impairment on brain iron levels and cerebral oxygen …