Having made substantial progress understanding molecules, cells, genes and pathways,
aging biology research is now moving toward integration of these parts, attempting to …

Highlights•Microfluidics is transforming traditional techniques in biotechnology.•Multi-step
experiments are automated on single device in parallel reactors.•Millions of parallel …

Synthetic biology enables the design of gene networks to confer specific biological
functions, yet it remains a challenge to rationally engineer a biological trait as complex as …

Chromatin instability and mitochondrial decline are conserved processes that contribute to
cellular aging. Although both processes have been explored individually in the context of …

The complex processes and interactions that regulate aging and determine lifespan are not
fully defined for any organism. Here, taking advantage of recent technological advances in …

It has been nearly three decades since the budding yeast Saccharomyces cerevisiae
became a significant model organism for aging research and it has emerged as both simple …

Transcription of protein coding genes is accompanied by recruitment of COMPASS to
promoter-proximal chromatin, which methylates histone H3 lysine 4 (H3K4) to form …

Synthetic biology is the design and modification of biological systems for specific functions,
integrating several disciplines like engineering, genetics, and computer science. The field of …

Single-cell genetic screens can be incredibly powerful, but current high-throughput platforms
do not track dynamic processes, and even for non-dynamic properties they struggle to …

Single-cell image analysis provides a powerful approach for studying cell-to-cell
heterogeneity, which is an important attribute of isogenic cell populations, from microbial …