Computational pharmaceutics-A new paradigm of drug delivery

W Wang, Z Ye, H Gao, D Ouyang - Journal of Controlled Release, 2021 - Elsevier
In recent decades pharmaceutics and drug delivery have become increasingly critical in the
pharmaceutical industry due to longer time, higher cost, and less productivity of new …

A review on the modernization of pharmaceutical development and manufacturing–Trends, perspectives, and the role of mathematical modeling

F Destro, M Barolo - International Journal of Pharmaceutics, 2022 - Elsevier
Recently, the pharmaceutical industry has been facing several challenges associated to the
use of outdated development and manufacturing technologies. The return on investment on …

Integrated continuous pharmaceutical technologies—a review

A Domokos, B Nagy, B Szilagyi, G Marosi… - … Process Research & …, 2021 - ACS Publications
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

Process analytical technology tools for monitoring pharmaceutical unit operations: a control strategy for continuous process verification

EJ Kim, JH Kim, MS Kim, SH Jeong, DH Choi - Pharmaceutics, 2021 - mdpi.com
Various frameworks and methods, such as quality by design (QbD), real time release test
(RTRT), and continuous process verification (CPV), have been introduced to improve drug …

Recent progress in continuous manufacturing of oral solid dosage forms

V Vanhoorne, C Vervaet - International Journal of Pharmaceutics, 2020 - Elsevier
Continuous drug product manufacturing is slowly being implemented in the pharmaceutical
industry. Although the benefits related to the quality and cost of continuous manufacturing …

[HTML][HTML] Applications of machine vision in pharmaceutical technology: A review

DL Galata, LA Meszaros, N Kallai-Szabo… - European Journal of …, 2021 - Elsevier
The goal of this paper is to give an introduction to analysis of images acquired by a digital
camera with visible illumination and to review its applications as a Process Analytical …

A review of in-line and on-line measurement techniques to monitor industrial mixing processes

AL Bowler, S Bakalis, NJ Watson - Chemical Engineering Research and …, 2020 - Elsevier
Mixing is a ubiquitous operation in process engineering. It is not only used for combining
materials, but also for promoting heat and mass transfer, increasing aeration, suspending …

Hot-melt extrusion: Highlighting recent advances in pharmaceutical applications

S Tambe, D Jain, Y Agarwal, P Amin - Journal of Drug Delivery Science …, 2021 - Elsevier
Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for
pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost …

Quality evaluation of traditional Chinese medicines based on fingerprinting

X Liu, W Jiang, M Su, Y Sun, H Liu… - Journal of separation …, 2020 - Wiley Online Library
The usage of traditional Chinese medicines has expanded globally, but the data about
authentication, efficacy, and safety is far from sufficient to meet the criteria supporting their …

[HTML][HTML] End-to-end continuous manufacturing of conventional compressed tablets: From flow synthesis to tableting through integrated crystallization and filtration

A Domokos, B Nagy, M Gyürkés, A Farkas… - International journal of …, 2020 - Elsevier
An end-to-end continuous pharmaceutical manufacturing process was developed for the
production of conventional direct compressed tablets on a proof-of-concept level for the first …