Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts

MP Stewart, R Langer, KF Jensen - Chemical reviews, 2018 - ACS Publications
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Micro-and macrorheology of mucus

SK Lai, YY Wang, D Wirtz, J Hanes - Advanced drug delivery reviews, 2009 - Elsevier
Mucus is a complex biological material that lubricates and protects the human lungs,
gastrointestinal (GI) tract, vagina, eyes, and other moist mucosal surfaces. Mucus serves as …

Current status of bioinks for micro-extrusion-based 3D bioprinting

A Panwar, LP Tan - Molecules, 2016 - mdpi.com
Recent developments in 3D printing technologies and design have been nothing short of
spectacular. Parallel to this, development of bioinks has also emerged as an active research …

Mechanics, malignancy, and metastasis: the force journey of a tumor cell

S Kumar, VM Weaver - Cancer and Metastasis Reviews, 2009 - Springer
A cell undergoes many genetic and epigenetic changes as it transitions to malignancy.
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …

Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties

T Panciera, A Citron, D Di Biagio, G Battilana… - Nature materials, 2020 - nature.com
Defining the interplay between the genetic events and microenvironmental contexts
necessary to initiate tumorigenesis in normal cells is a central endeavour in cancer biology …

Mechanical models for living cells—a review

CT Lim, EH Zhou, ST Quek - Journal of biomechanics, 2006 - Elsevier
As physical entities, living cells possess structural and physical properties that enable them
to withstand the physiological environment as well as mechanical stimuli occurring within …

Are cancer cells really softer than normal cells?

C Alibert, B Goud, JB Manneville - Biology of the Cell, 2017 - Wiley Online Library
Solid tumours are often first diagnosed by palpation, suggesting that the tumour is more rigid
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …

Broken detailed balance and non-equilibrium dynamics in living systems: a review

FS Gnesotto, F Mura, J Gladrow… - Reports on Progress in …, 2018 - iopscience.iop.org
Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce
broken detailed balance at the molecular scale. This molecular scale breaking of detailed …

Particle-tracking microrheology of living cells: principles and applications

D Wirtz - Annual review of biophysics, 2009 - annualreviews.org
A multitude of cellular and subcellular processes depend critically on the mechanical
deformability of the cytoplasm. We have recently introduced the method of particle-tracking …

Fluid mechanics of microrheology

TM Squires, TG Mason - Annual review of fluid mechanics, 2010 - annualreviews.org
In microrheology, the local and bulk mechanical properties of a complex fluid are extracted
from the motion of probe particles embedded within it. In passive microrheology, particles …