Intracellular delivery by membrane disruption: mechanisms, strategies, and concepts
Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
biomedical discoveries. It is also becoming increasingly important in industrial and medical …
Micro-and macrorheology of mucus
Mucus is a complex biological material that lubricates and protects the human lungs,
gastrointestinal (GI) tract, vagina, eyes, and other moist mucosal surfaces. Mucus serves as …
gastrointestinal (GI) tract, vagina, eyes, and other moist mucosal surfaces. Mucus serves as …
Current status of bioinks for micro-extrusion-based 3D bioprinting
Recent developments in 3D printing technologies and design have been nothing short of
spectacular. Parallel to this, development of bioinks has also emerged as an active research …
spectacular. Parallel to this, development of bioinks has also emerged as an active research …
Mechanics, malignancy, and metastasis: the force journey of a tumor cell
A cell undergoes many genetic and epigenetic changes as it transitions to malignancy.
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …
Reprogramming normal cells into tumour precursors requires ECM stiffness and oncogene-mediated changes of cell mechanical properties
T Panciera, A Citron, D Di Biagio, G Battilana… - Nature materials, 2020 - nature.com
Defining the interplay between the genetic events and microenvironmental contexts
necessary to initiate tumorigenesis in normal cells is a central endeavour in cancer biology …
necessary to initiate tumorigenesis in normal cells is a central endeavour in cancer biology …
Mechanical models for living cells—a review
As physical entities, living cells possess structural and physical properties that enable them
to withstand the physiological environment as well as mechanical stimuli occurring within …
to withstand the physiological environment as well as mechanical stimuli occurring within …
Are cancer cells really softer than normal cells?
Solid tumours are often first diagnosed by palpation, suggesting that the tumour is more rigid
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …
than its surrounding environment. Paradoxically, individual cancer cells appear to be softer …
Broken detailed balance and non-equilibrium dynamics in living systems: a review
FS Gnesotto, F Mura, J Gladrow… - Reports on Progress in …, 2018 - iopscience.iop.org
Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce
broken detailed balance at the molecular scale. This molecular scale breaking of detailed …
broken detailed balance at the molecular scale. This molecular scale breaking of detailed …
Particle-tracking microrheology of living cells: principles and applications
D Wirtz - Annual review of biophysics, 2009 - annualreviews.org
A multitude of cellular and subcellular processes depend critically on the mechanical
deformability of the cytoplasm. We have recently introduced the method of particle-tracking …
deformability of the cytoplasm. We have recently introduced the method of particle-tracking …
Fluid mechanics of microrheology
In microrheology, the local and bulk mechanical properties of a complex fluid are extracted
from the motion of probe particles embedded within it. In passive microrheology, particles …
from the motion of probe particles embedded within it. In passive microrheology, particles …