Tyrosine, phenylalanine and tryptophan are the three aromatic amino acids (AAA) involved
in protein synthesis. These amino acids and their metabolism are linked to the synthesis of a …

Covering: 1997 to 2023 The shikimate pathway is the metabolic process responsible for the
biosynthesis of the aromatic amino acids phenylalanine, tyrosine, and tryptophan. Seven …

The two-volume Encyclopedia of Supramolecular Chemistry offers authoritative, centralized
information on a rapidly expanding interdisciplinary field. User-friendly and high-quality …

Absent in animals and with only seven enzymatic reactions toward the synthesis of
chorismate and aromatic amino acids, the shikimate pathway is a crucial target for …

Since convergent evolution of enzyme active sites was first identified in serine proteases,
other individual instances of this phenomenon have been documented. However, a …

Shikimate dehydrogenase catalyzes the fourth step of the shikimate pathway, the essential
route for the biosynthesis of aromatic compounds in plants and microorganisms. Absent in …

The binding between two biomolecules is one of the most critical factors controlling many
bioprocesses. Therefore, it is of great interest to derive a reliable method to calculate the free …

Roughly a third of the world's population is estimated to have latent Mycobacterium
tuberculosis infection, being at risk of develo** active tuberculosis (TB) during their …

The background and current context of work on the shikimate-pathway enzymes as potential
targets for anti-bacterial, anti-fungal and anti-parasitic drugs is reviewed. Recent work on the …

One of the initial steps of modern drug discovery is the identification of small organic
molecules able to inhibit a target macromolecule of therapeutic interest. A small proportion …