Half a century of amyloids: past, present and future

PC Ke, R Zhou, LC Serpell, R Riek… - Chemical Society …, 2020 - pubs.rsc.org
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

[HTML][HTML] Amyloid precursor protein and Alzheimer's disease

KS Orobets, AL Karamyshev - International journal of molecular sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders
associated with age or inherited mutations. It is characterized by severe dementia in the late …

Endothelial leakiness elicited by amyloid protein aggregation

Y Li, N Ni, M Lee, W Wei, N Andrikopoulos… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) is a major cause of dementia debilitating the global ageing
population. Current understanding of the AD pathophysiology implicates the aggregation of …

[HTML][HTML] The amyloid state of proteins in human diseases

D Eisenberg, M Jucker - Cell, 2012 - cell.com
Amyloid fibers and oligomers are associated with a great variety of human diseases
including Alzheimer's disease and the prion conditions. Here we attempt to connect recent …

Natural product-based amyloid inhibitors

P Velander, L Wu, F Henderson, S Zhang… - Biochemical …, 2017 - Elsevier
Many chronic human diseases, including multiple neurodegenerative diseases, are
associated with deleterious protein aggregates, also called protein amyloids. One common …

Monitoring and inhibition of insulin fibrillation by a small organic fluorogen with aggregation-induced emission characteristics

Y Hong, L Meng, S Chen, CWT Leung… - Journal of the …, 2012 - ACS Publications
Amyloid fibrillation of proteins is associated with a great variety of pathologic conditions.
Development of new molecules that can monitor amyloidosis kinetics and inhibit fibril …

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease

J Habchi, S Chia, R Limbocker, B Mannini… - Proceedings of the …, 2017 - pnas.org
The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in
Alzheimer's disease (AD). The use of chemical kinetics has recently enabled highly accurate …

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease

J Habchi, P Arosio, M Perni, AR Costa… - Science …, 2016 - science.org
The conversion of the β-amyloid (Aβ) peptide into pathogenic aggregates is linked to the
onset and progression of Alzheimer's disease. Although this observation has prompted an …

Inhibition of amyloid formation

T Härd, C Lendel - Journal of molecular biology, 2012 - Elsevier
Amyloid is aggregated protein in the form of insoluble fibrils. Amyloid deposition in human
tissue—amyloidosis—is associated with a number of diseases including all common …

Impact of nanoparticles on amyloid peptide and protein aggregation: a review with a focus on gold nanoparticles

T John, A Gladytz, C Kubeil, LL Martin, HJ Risselada… - Nanoscale, 2018 - pubs.rsc.org
Society is increasingly exposed to nanoparticles as they are ubiquitous in nature and
introduced as man-made air pollutants and as functional ingredients in cosmetic products as …