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Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
[HTML][HTML] Amyloid precursor protein and Alzheimer's disease
KS Orobets, AL Karamyshev - International journal of molecular sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders
associated with age or inherited mutations. It is characterized by severe dementia in the late …
associated with age or inherited mutations. It is characterized by severe dementia in the late …
Endothelial leakiness elicited by amyloid protein aggregation
Alzheimer's disease (AD) is a major cause of dementia debilitating the global ageing
population. Current understanding of the AD pathophysiology implicates the aggregation of …
population. Current understanding of the AD pathophysiology implicates the aggregation of …
[HTML][HTML] The amyloid state of proteins in human diseases
D Eisenberg, M Jucker - Cell, 2012 - cell.com
Amyloid fibers and oligomers are associated with a great variety of human diseases
including Alzheimer's disease and the prion conditions. Here we attempt to connect recent …
including Alzheimer's disease and the prion conditions. Here we attempt to connect recent …
Natural product-based amyloid inhibitors
P Velander, L Wu, F Henderson, S Zhang… - Biochemical …, 2017 - Elsevier
Many chronic human diseases, including multiple neurodegenerative diseases, are
associated with deleterious protein aggregates, also called protein amyloids. One common …
associated with deleterious protein aggregates, also called protein amyloids. One common …
Monitoring and inhibition of insulin fibrillation by a small organic fluorogen with aggregation-induced emission characteristics
Amyloid fibrillation of proteins is associated with a great variety of pathologic conditions.
Development of new molecules that can monitor amyloidosis kinetics and inhibit fibril …
Development of new molecules that can monitor amyloidosis kinetics and inhibit fibril …
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease
The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in
Alzheimer's disease (AD). The use of chemical kinetics has recently enabled highly accurate …
Alzheimer's disease (AD). The use of chemical kinetics has recently enabled highly accurate …
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease
The conversion of the β-amyloid (Aβ) peptide into pathogenic aggregates is linked to the
onset and progression of Alzheimer's disease. Although this observation has prompted an …
onset and progression of Alzheimer's disease. Although this observation has prompted an …
Inhibition of amyloid formation
Amyloid is aggregated protein in the form of insoluble fibrils. Amyloid deposition in human
tissue—amyloidosis—is associated with a number of diseases including all common …
tissue—amyloidosis—is associated with a number of diseases including all common …
Impact of nanoparticles on amyloid peptide and protein aggregation: a review with a focus on gold nanoparticles
Society is increasingly exposed to nanoparticles as they are ubiquitous in nature and
introduced as man-made air pollutants and as functional ingredients in cosmetic products as …
introduced as man-made air pollutants and as functional ingredients in cosmetic products as …