ALS: a disease of motor neurons and their nonneuronal neighbors
Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease
affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of …
affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of …
Stem cell therapy for human neurodegenerative disorders–how to make it work
Recent progress shows that neurons suitable for transplantation can be generated from
stem cells in culture, and that the adult brain produces new neurons from its own stem cells …
stem cells in culture, and that the adult brain produces new neurons from its own stem cells …
Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
Gain-of-function mutations in the Cu, Zn-superoxide dismutase (SOD1) gene are implicated
in progressive motor neuron death and paralysis in one form of inherited amyotrophic lateral …
in progressive motor neuron death and paralysis in one form of inherited amyotrophic lateral …
Focal transplantation–based astrocyte replacement is neuroprotective in a model of motor neuron disease
Cellular abnormalities in amyotrophic lateral sclerosis (ALS) are not limited to motor
neurons. Astrocyte dysfunction also occurs in human ALS and transgenic rodents …
neurons. Astrocyte dysfunction also occurs in human ALS and transgenic rodents …
Stem cell technology for neurodegenerative diseases
Over the past 20 years, stem cell technologies have become an increasingly attractive
option to investigate and treat neurodegenerative diseases. In the current review, we …
option to investigate and treat neurodegenerative diseases. In the current review, we …
Intravenous mesenchymal stem cell therapy for traumatic brain injury
MT Harting, F Jimenez, H Xue, UM Fischer… - Journal of …, 2009 - thejns.org
Object Cell therapy has shown preclinical promise in the treatment of many diseases, and its
application is being translated to the clinical arena. Intravenous mesenchymal stem cell …
application is being translated to the clinical arena. Intravenous mesenchymal stem cell …
Astrocyte function and role in motor neuron disease: a future therapeutic target?
Astrocytes are the most numerous cell type within the central nervous system (CNS) and
perform a variety of tasks, from axon guidance and synaptic support, to the control of the …
perform a variety of tasks, from axon guidance and synaptic support, to the control of the …
Ultrastructure of blood–brain barrier and blood–spinal cord barrier in SOD1 mice modeling ALS
S Garbuzova-Davis, E Haller, S Saporta, I Kolomey… - Brain research, 2007 - Elsevier
The purpose of this study was to determine the ultrastructure of the blood–brain barrier
(BBB) and blood–spinal cord barrier (BSCB) in G93A SOD1 mice modeling ALS at different …
(BBB) and blood–spinal cord barrier (BSCB) in G93A SOD1 mice modeling ALS at different …
Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model
HL Feng, Y Leng, CH Ma, J Zhang, M Ren, DM Chuang - Neuroscience, 2008 - Elsevier
Lithium and valproic acid (VPA) are two primary drugs used to treat bipolar disorder, and
have been shown to have neuroprotective properties in vivo and in vitro. A recent study …
have been shown to have neuroprotective properties in vivo and in vitro. A recent study …
Cord blood rescues stroke-induced changes in splenocyte phenotype and function
M Vendrame, C Gemma, KR Pennypacker… - Experimental …, 2006 - Elsevier
The neuroprotective mechanism of human umbilical cord blood cells (HUCBC) in the rat
middle cerebral artery occlusion (MCAO) stroke model remains uncertain. Given the …
middle cerebral artery occlusion (MCAO) stroke model remains uncertain. Given the …