Oxidative stress in cancer cell metabolism
Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …
whereas deregulated ROS leads to the development of a diseased state in humans …
NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets
Y Zhang, P Murugesan, K Huang, H Cai - Nature Reviews Cardiology, 2020 - nature.com
Reactive oxygen species (ROS)-dependent production of ROS underlies sustained
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …
oxidative stress, which has been implicated in the pathogenesis of cardiovascular diseases …
Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers
There are multiple sources of reactive oxygen species (ROS) in the cell. As a major site of
ROS production, mitochondria have drawn considerable interest because it was recently …
ROS production, mitochondria have drawn considerable interest because it was recently …
Blockade of GCH1/BH4 axis activates ferritinophagy to mitigate the resistance of colorectal cancer to erastin-induced ferroptosis
Q Hu, W Wei, D Wu, F Huang, M Li, W Li… - Frontiers in cell and …, 2022 - frontiersin.org
Ferroptosis, a type of cell death triggered by excessive accumulation of iron-dependent lipid
peroxidation, possesses an excellent potential in cancer treatment. However, many …
peroxidation, possesses an excellent potential in cancer treatment. However, many …
Mitochondria as a therapeutic target in heart failure
M Bayeva, M Gheorghiade, H Ardehali - Journal of the American College of …, 2013 - jacc.org
Heart failure is a pressing public health problem with no curative treatment currently
available. The existing therapies provide symptomatic relief, but are unable to reverse …
available. The existing therapies provide symptomatic relief, but are unable to reverse …
Oxidative stress and hypertension: current concepts
AM Briones, RM Touyz - Current hypertension reports, 2010 - Springer
Hypertension is a major contributor to the development of renal failure, cardiovascular
disease, and stroke. These pathologies are associated with vascular functional and …
disease, and stroke. These pathologies are associated with vascular functional and …
Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease
The metabolic syndrome is a constellation of metabolic disorders including obesity,
hypertension, and insulin resistance, components which are risk factors for the development …
hypertension, and insulin resistance, components which are risk factors for the development …
Red blood cell dysfunction: a new player in cardiovascular disease
The primary role of red blood cells (RBCs) is to transport oxygen to the tissues and carbon
dioxide to the lungs. However, emerging evidence suggests an important role of the RBC …
dioxide to the lungs. However, emerging evidence suggests an important role of the RBC …
FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity
Defective mitophagy is causally linked to obesity complications. Here, we identified an
interaction between mitophagy protein FUNDC1 (FUN14 domain containing 1) and receptor …
interaction between mitophagy protein FUNDC1 (FUN14 domain containing 1) and receptor …
Mitochondrial reactive oxygen species mediate lysophosphatidylcholine-induced endothelial cell activation
Objective—Hyperlipidemia-induced endothelial cell (EC) activation is considered as an
initial event responsible for monocyte recruitment in atherogenesis. However, it remains …
initial event responsible for monocyte recruitment in atherogenesis. However, it remains …