Importance Preeclampsia is a hypertensive disorder of pregnancy that poses serious
maternal and infant health risks. Previous systematic reviews have established benefits of …

Importance Vitamin D and calcium supplements are recommended for the prevention of
fracture, but previous randomized clinical trials (RCTs) have reported conflicting results, with …

Doing Meta-Analysis with R: A Hands-On Guide serves as an accessible introduction on
how meta-analyses can be conducted in R. Essential steps for meta-analysis are covered …

Background Inclisiran, an siRNA administered twice-yearly, significantly reduced LDL
cholesterol (LDL-C) in Phase III trials. Whether lowering LDL-C with inclisiran translates into …

Abstract Background and purpose The Meta-Analysis of Chemotherapy in squamous cell
Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) …

Background Diabetes mellitus is associated with an increased risk of cardiovascular events.
Aspirin use reduces the risk of occlusive vascular events but increases the risk of bleeding; …

This chapter describes the principles and methods used to carry out a meta‐analysis for a
comparison of two interventions for the main types of data encountered. A very common and …

This article explains a decision rule that uses Bayesian posterior distributions as the basis
for accepting or rejecting null values of parameters. This decision rule focuses on the range …

Background Patients with atherosclerotic vascular disease remain at high risk for
cardiovascular events despite effective statin-based treatment of low-density lipoprotein …

The use of evidence from clinical trials to support decisions for individual patients is a form of
“reference class forecasting”: implicit predictions for an individual are made on the basis of …