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Adult neurogenesis in the mammalian brain: significant answers and significant questions
Adult neurogenesis, a process of generating functional neurons from adult neural
precursors, occurs throughout life in restricted brain regions in mammals. The past decade …
precursors, occurs throughout life in restricted brain regions in mammals. The past decade …
Pattern separation: a common function for new neurons in hippocampus and olfactory bulb
While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of
the hippocampus have fundamentally different properties, they may have more in common …
the hippocampus have fundamentally different properties, they may have more in common …
Involvement of adult hippocampal neurogenesis in learning and forgetting
Adult hippocampal neurogenesis is a process involving the continuous generation of
newborn neurons in the hippocampus of adult animals. Mounting evidence has suggested …
newborn neurons in the hippocampus of adult animals. Mounting evidence has suggested …
Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology
Human neural progenitors derived from pluripotent stem cells develop into
electrophysiologically active neurons at heterogeneous rates, which can confound disease …
electrophysiologically active neurons at heterogeneous rates, which can confound disease …
Functional properties of cortical feedback projections to the olfactory bulb
Sensory perception is not a simple feed-forward process, and higher brain areas can
actively modulate information processing in" lower" areas. We used optogenetic methods to …
actively modulate information processing in" lower" areas. We used optogenetic methods to …
Activation of adult-born neurons facilitates learning and memory
M Alonso, G Lepousez, S Wagner, C Bardy… - Nature …, 2012 - nature.com
Thousand of local interneurons reach the olfactory bulb of adult rodents every day, but the
functional effect of this process remains elusive. By selectively expressing channelrhodopsin …
functional effect of this process remains elusive. By selectively expressing channelrhodopsin …
Development of the mammalian main olfactory bulb
C Tufo, S Poopalasundaram, A Dorrego-Rivas… - …, 2022 - journals.biologists.com
The mammalian main olfactory bulb is a crucial processing centre for the sense of smell. The
olfactory bulb forms early during development and is functional from birth. However, the …
olfactory bulb forms early during development and is functional from birth. However, the …
Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb
Identifying the connectome of adult-generated neurons is essential for understanding how
the preexisting circuitry is refined by neurogenesis. Changes in the pattern of connectivity …
the preexisting circuitry is refined by neurogenesis. Changes in the pattern of connectivity …
[HTML][HTML] Integration of GABAergic interneurons into cortical cell assemblies: lessons from embryos and adults
In the forebrain, cortical structures consist of networks of excitatory and inhibitory neurons
born in distant locations. Understanding how these two major classes of neurons integrate …
born in distant locations. Understanding how these two major classes of neurons integrate …
Adult neurogenesis and the future of the rejuvenating brain circuits
G Lepousez, A Nissant, PM Lledo - Neuron, 2015 - cell.com
For a long time, the mammalian brain has been perceived to be a static organ. However, the
discovery of adult neurogenesis in most mammalian species, including humans, monkeys …
discovery of adult neurogenesis in most mammalian species, including humans, monkeys …