In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of major heart
failure events, an action that is statistically linked to enhanced erythropoiesis, suggesting …

Iron is an essential micro-element, involved in multiple biological activities in vertebrates.
Excess iron accumulation has been identified as an important mediator of lipid deposition …

Homeostatic adaptation to systemic iron overload involves transcriptional induction of bone
morphogenetic protein 6 (BMP6) in liver sinusoidal endothelial cells (LSECs). BMP6 is then …

The purpose of the study was to investigate the expression of ferroportin protein following
treatments that affect systemic hepcidin. Administration of erythropoietin to C57BL/6J mice …

Deferoxamine (DFO) is a water-soluble iron chelator used pharmacologically for the
management of patients with transfusional iron overload. However, DFO is not cell …

The survival, growth, and virulence of Leishmania spp., a group of protozoan parasites,
depends on the proper access and regulation of iron. Macrophages, Leishmania's host cell …

Iron regulatory protein 1 (IRP1) is a bifunctional protein with mutually exclusive RNA-binding
or enzymatic activities that depend on the presence of a 4Fe-4S cluster. While IRP1 is a well …

Intravenous injection of excess apotransferrin enhances dietary iron absorption in mice and
triggers accumulation of plasma non–transferrin-bound iron. Injected fluorescent-labeled …

The iron hormone hepcidin is transcriptionally activated by iron or inflammation via distinct,
partially overlap** pathways. We addressed how iron affects inflammatory hepcidin levels …